Tyrosine-protein kinase JAK1
Intramolecular
Cysteine 1116 and cysteine 1120 L
Cysteine 445 and cysteine 469
Cysteine 543 and cysteine 544
Cysteine 787 and cysteine 817 L
Cysteine 752 and cysteine 763
Cysteine 988 and cysteine 1131
Cysteine 440 and cysteine 543
Cysteine 169 and cysteine 189 L
Cysteine 892 and cysteine 944 L
Cysteine 74 and cysteine 469
5khx A 1116 A 1120
A redox-regulated disulphide may form within Tyrosine-protein kinase JAK1 between cysteines 1116 and 1120.
Details
Redox score ?
82
PDB code
5khx
Structure name
crystal structure of jak1 in complex with pf-4950736
Structure deposition date
2016-06-16
Thiol separation (Å)
3
Half-sphere exposure sum ?
52
Minimum pKa ?
9
% buried
26
Peptide accession
P23458
Residue number A
1116
Residue number B
1120
Peptide name
Tyrosine-protein kinase JAK1
Ligandability
Cysteine 1116 of Tyrosine-protein kinase JAK1
Cysteine 1120 of Tyrosine-protein kinase JAK1
5ixd A 445 A 469
A redox-regulated disulphide may form within Tyrosine-protein kinase JAK1 between cysteines 445 and 469.
Details
Redox score ?
62
PDB code
5ixd
Structure name
structure of human jak1 ferm/sh2 in complex with ifn lambda receptor
Structure deposition date
2016-03-23
Thiol separation (Å)
6
Half-sphere exposure sum ?
52
Minimum pKa ?
10
% buried
24
Peptide accession
P23458
Residue number A
445
Residue number B
469
Peptide name
Tyrosine-protein kinase JAK1
Ligandability
Cysteine 445 of Tyrosine-protein kinase JAK1
Cysteine 469 of Tyrosine-protein kinase JAK1
5l04 A 543 A 544
A redox-regulated disulphide may form within Tyrosine-protein kinase JAK1 between cysteines 543 and 544. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
5l04
Structure name
structure of interferon lambda 1 receptor with human kinase jak1
Structure deposition date
2016-07-26
Thiol separation (Å)
7
Half-sphere exposure sum ?
66
Minimum pKa ?
11
% buried
60
Peptide accession
P23458
Residue number A
543
Residue number B
544
Peptide name
Tyrosine-protein kinase JAK1
Ligandability
Cysteine 543 of Tyrosine-protein kinase JAK1
Cysteine 544 of Tyrosine-protein kinase JAK1
4l01 B 787 B 817
A redox-regulated disulphide may form within Tyrosine-protein kinase JAK1 between cysteines 787 and 817. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
4l01
Structure name
crystal structure of the v658f apo jak1 pseudokinase domain
Structure deposition date
2013-05-30
Thiol separation (Å)
8
Half-sphere exposure sum ?
50
Minimum pKa ?
9
% buried
24
Peptide accession
P23458
Residue number A
787
Residue number B
817
Peptide name
Tyrosine-protein kinase JAK1
Ligandability
Cysteine 787 of Tyrosine-protein kinase JAK1
Cysteine 817 of Tyrosine-protein kinase JAK1
4l01 A 752 A 763
A redox-regulated disulphide may form within Tyrosine-protein kinase JAK1 between cysteines 752 and 763. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
4l01
Structure name
crystal structure of the v658f apo jak1 pseudokinase domain
Structure deposition date
2013-05-30
Thiol separation (Å)
7
Half-sphere exposure sum ?
75
Minimum pKa ?
11
% buried
79
Peptide accession
P23458
Residue number A
752
Residue number B
763
Peptide name
Tyrosine-protein kinase JAK1
Ligandability
Cysteine 752 of Tyrosine-protein kinase JAK1
Cysteine 763 of Tyrosine-protein kinase JAK1
4k6z A 988 A 1131
A redox-regulated disulphide may form within Tyrosine-protein kinase JAK1 between cysteines 988 and 1131. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
4k6z
Structure name
the jak1 kinase domain in complex with compound 37
Structure deposition date
2013-04-16
Thiol separation (Å)
7
Half-sphere exposure sum ?
81
Minimum pKa ?
12
% buried
100
Peptide accession
P23458
Residue number A
988
Residue number B
1131
Peptide name
Tyrosine-protein kinase JAK1
Ligandability
Cysteine 988 of Tyrosine-protein kinase JAK1
Cysteine 1131 of Tyrosine-protein kinase JAK1
5l04 A 440 A 543
A redox-regulated disulphide may form within Tyrosine-protein kinase JAK1 between cysteines 440 and 543. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
5l04
Structure name
structure of interferon lambda 1 receptor with human kinase jak1
Structure deposition date
2016-07-26
Thiol separation (Å)
8
Half-sphere exposure sum ?
69
Minimum pKa ?
11
% buried
88
Peptide accession
P23458
Residue number A
440
Residue number B
543
Peptide name
Tyrosine-protein kinase JAK1
Ligandability
Cysteine 440 of Tyrosine-protein kinase JAK1
Cysteine 543 of Tyrosine-protein kinase JAK1
5ixd A 169 A 189
A redox-regulated disulphide may form within Tyrosine-protein kinase JAK1 between cysteines 169 and 189. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
5ixd
Structure name
structure of human jak1 ferm/sh2 in complex with ifn lambda receptor
Structure deposition date
2016-03-23
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
9
% buried
67
Peptide accession
P23458
Residue number A
169
Residue number B
189
Peptide name
Tyrosine-protein kinase JAK1
Ligandability
Cysteine 169 of Tyrosine-protein kinase JAK1
Cysteine 189 of Tyrosine-protein kinase JAK1
6aah A 892 A 944
A redox-regulated disulphide may form within Tyrosine-protein kinase JAK1 between cysteines 892 and 944. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
6aah
Structure name
crystal structure of jak1 in complex with peficitinib
Structure deposition date
2018-07-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
69
Minimum pKa ?
10
% buried
75
Peptide accession
P23458
Residue number A
892
Residue number B
944
Peptide name
Tyrosine-protein kinase JAK1
Ligandability
Cysteine 892 of Tyrosine-protein kinase JAK1
Cysteine 944 of Tyrosine-protein kinase JAK1
5ixd A 74 A 469
A redox-regulated disulphide may form within Tyrosine-protein kinase JAK1 between cysteines 74 and 469. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
5ixd
Structure name
structure of human jak1 ferm/sh2 in complex with ifn lambda receptor
Structure deposition date
2016-03-23
Thiol separation (Å)
10
Half-sphere exposure sum ?
68
Minimum pKa ?
10
% buried
57
Peptide accession
P23458
Residue number A
74
Residue number B
469
Peptide name
Tyrosine-protein kinase JAK1
Ligandability
Cysteine 74 of Tyrosine-protein kinase JAK1
Cysteine 469 of Tyrosine-protein kinase JAK1
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