ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Receptor-type tyrosine-protein phosphatase beta

Intramolecular
Cysteine 1804 and cysteine 1812
Cysteine 1812 and cysteine 1904
A redox-regulated disulphide may form within Receptor-type tyrosine-protein phosphatase beta between cysteines 1804 and 1812.

Details

Redox score ?
71
PDB code
2h03
Structure name
structural studies of protein tyrosine phosphatase beta catalytic domain in complex with inhibitors
Structure deposition date
2006-05-13
Thiol separation (Å)
5
Half-sphere exposure sum ?
64
Minimum pKa ?
7
% buried
82
Peptide accession
Q3MIV7
Residue number A
1804
Residue number B
1812
Peptide name
Receptor-type tyrosine-protein phosphatase beta

Ligandability

Cysteine 1804 of Receptor-type tyrosine-protein phosphatase beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1812 of Receptor-type tyrosine-protein phosphatase beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Receptor-type tyrosine-protein phosphatase beta between cysteines 1812 and 1904. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
2h02
Structure name
structural studies of protein tyrosine phosphatase beta catalytic domain in complex with inhibitors
Structure deposition date
2006-05-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
81
Minimum pKa ?
5
% buried
100
Peptide accession
Q3MIV7
Residue number A
1812
Residue number B
1904
Peptide name
Receptor-type tyrosine-protein phosphatase beta

Ligandability

Cysteine 1812 of Receptor-type tyrosine-protein phosphatase beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1904 of Receptor-type tyrosine-protein phosphatase beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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