ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Receptor-type tyrosine-protein phosphatase delta

Intramolecular
Cysteine 257 and cysteine 302
Cysteine 45 and cysteine 98
Cysteine 147 and cysteine 207
Cysteine 1754 and cysteine 1844
A redox-regulated disulphide may form within Receptor-type tyrosine-protein phosphatase delta between cysteines 257 and 302 (248 and 293 respectively in this structure).

Details

Redox score ?
83
PDB code
5xnp
Structure name
crystal structures of human salm5 in complex with human ptpdelta
Structure deposition date
2017-05-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
P23468
Residue number A
257
Residue number B
302
Peptide name
Receptor-type tyrosine-protein phosphatase delta

Ligandability

Cysteine 257 of Receptor-type tyrosine-protein phosphatase delta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 302 of Receptor-type tyrosine-protein phosphatase delta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Receptor-type tyrosine-protein phosphatase delta between cysteines 45 and 98 (52 and 105 respectively in this structure).

Details

Redox score ?
82
PDB code
7ceg
Structure name
crystal structure of the complex between mouse ptp delta and neuroligin-3
Structure deposition date
2020-06-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q64487
Residue number A
45
Residue number B
98
Peptide name
Receptor-type tyrosine-protein phosphatase delta

Ligandability

Cysteine 45 of Receptor-type tyrosine-protein phosphatase delta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 98 of Receptor-type tyrosine-protein phosphatase delta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Receptor-type tyrosine-protein phosphatase delta between cysteines 147 and 207.

Details

Redox score ?
81
PDB code
4rca
Structure name
crystal structure of human ptpdelta and human slitrk1 complex
Structure deposition date
2014-09-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide accession
P23468
Residue number A
147
Residue number B
207
Peptide name
Receptor-type tyrosine-protein phosphatase delta

Ligandability

Cysteine 147 of Receptor-type tyrosine-protein phosphatase delta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 207 of Receptor-type tyrosine-protein phosphatase delta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Receptor-type tyrosine-protein phosphatase delta between cysteines 1754 and 1844 (1350 and 1440 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
6kip
Structure name
crystal structure of ptprd phosphatase domain in complex with liprin- alpha3 tandem sam domains
Structure deposition date
2019-07-19
Thiol separation (Å)
10
Half-sphere exposure sum ?
75
Minimum pKa ?
8
% buried
98
Peptide accession
Q64487
Residue number A
1754
Residue number B
1844
Peptide name
Receptor-type tyrosine-protein phosphatase delta

Ligandability

Cysteine 1754 of Receptor-type tyrosine-protein phosphatase delta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1844 of Receptor-type tyrosine-protein phosphatase delta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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