ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Receptor-type tyrosine-protein phosphatase gamma

Intramolecular
Cysteine 78 and cysteine 261
Cysteine 961 and cysteine 1060
A redox-regulated disulphide may form within Receptor-type tyrosine-protein phosphatase gamma between cysteines 78 and 261.

Details

Redox score ?
86
PDB code
5e5r
Structure name
crystal structure of the complex between carbonic anhydrase-like domain of ptprg and immunoglobulin domains 2-3 of cntn3
Structure deposition date
2015-10-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P23470
Residue number A
78
Residue number B
261
Peptide name
Receptor-type tyrosine-protein phosphatase gamma

Ligandability

Cysteine 78 of Receptor-type tyrosine-protein phosphatase gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 261 of Receptor-type tyrosine-protein phosphatase gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Receptor-type tyrosine-protein phosphatase gamma between cysteines 961 and 1060. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
2hy3
Structure name
crystal structure of the human tyrosine receptor phosphate gamma in complex with vanadate
Structure deposition date
2006-08-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P23470
Residue number A
961
Residue number B
1060
Peptide name
Receptor-type tyrosine-protein phosphatase gamma

Ligandability

Cysteine 961 of Receptor-type tyrosine-protein phosphatase gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1060 of Receptor-type tyrosine-protein phosphatase gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: