ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Receptor-type tyrosine-protein phosphatase zeta

Intramolecular
Cysteine 56 and cysteine 240
Cysteine 133 and cysteine 264
Cysteine 1838 and cysteine 1934
A redox-regulated disulphide may form within Receptor-type tyrosine-protein phosphatase zeta between cysteines 56 and 240.

Details

Redox score ?
86
PDB code
3s97
Structure name
ptprz cntn1 complex
Structure deposition date
2011-05-31
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
P23471
Residue number A
56
Residue number B
240
Peptide name
Receptor-type tyrosine-protein phosphatase zeta

Ligandability

Cysteine 56 of Receptor-type tyrosine-protein phosphatase zeta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 240 of Receptor-type tyrosine-protein phosphatase zeta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Receptor-type tyrosine-protein phosphatase zeta between cysteines 133 and 264.

Details

Redox score ?
82
PDB code
3s97
Structure name
ptprz cntn1 complex
Structure deposition date
2011-05-31
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P23471
Residue number A
133
Residue number B
264
Peptide name
Receptor-type tyrosine-protein phosphatase zeta

Ligandability

Cysteine 133 of Receptor-type tyrosine-protein phosphatase zeta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 264 of Receptor-type tyrosine-protein phosphatase zeta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Receptor-type tyrosine-protein phosphatase zeta between cysteines 1838 and 1934. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
6j6u
Structure name
rat ptprz d1-d2 domain
Structure deposition date
2019-01-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
79
Minimum pKa ?
10
% buried
100
Peptide accession
Q62656
Residue number A
1838
Residue number B
1934
Peptide name
Receptor-type tyrosine-protein phosphatase zeta

Ligandability

Cysteine 1838 of Receptor-type tyrosine-protein phosphatase zeta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1934 of Receptor-type tyrosine-protein phosphatase zeta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: