ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Brain-derived neurotrophic factor

Intermolecular
Cysteine 239 and cysteine 248 of Neurotrophin-3
Cysteine 239 and cysteine 152 of Neurotrophin-3
Cysteine 141 and cysteine 248 of Neurotrophin-3
Cysteine 196 and cysteine 248 of Neurotrophin-3
Cysteine 239 and cysteine 205 of Neurotrophin-3
Intramolecular
Cysteine 141 and cysteine 208
Cysteine 186 and cysteine 237
Cysteine 196 and cysteine 239
Cysteine 196 and cysteine 208
Cysteine 141 and cysteine 196
More...
Cysteine 141 and cysteine 237
Cysteine 208 and cysteine 237
Cysteine 141 and cysteine 239
Cysteine 186 and cysteine 208
Cysteine 208 and cysteine 239
Cysteine 141 and cysteine 186
Cysteine 196 and cysteine 237
Cysteine 186 and cysteine 196
Cysteine 237 and cysteine 239
Cysteine 186 and cysteine 239
A redox-regulated disulphide may form between cysteine 239 of Brain-derived neurotrophic factor and cysteine 248 of Neurotrophin-3 (111 and 110 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
1bnd
Structure name
structure of the brain-derived neurotrophic factor(slash)neurotrophin 3 heterodimer
Structure deposition date
1994-12-12
Thiol separation (Å)
8
Half-sphere exposure sum ?
90
Minimum pKa ?
nan
% buried
nan
Peptide A name
Brain-derived neurotrophic factor
Peptide B name
Neurotrophin-3
Peptide A accession
P23560
Peptide B accession
P20783
Peptide A residue number
239
Peptide B residue number
248

Ligandability

Cysteine 239 of Brain-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 248 of Neurotrophin-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 239 of Brain-derived neurotrophic factor and cysteine 152 of Neurotrophin-3 (111 and 14 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
1bnd
Structure name
structure of the brain-derived neurotrophic factor(slash)neurotrophin 3 heterodimer
Structure deposition date
1994-12-12
Thiol separation (Å)
9
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide A name
Brain-derived neurotrophic factor
Peptide B name
Neurotrophin-3
Peptide A accession
P23560
Peptide B accession
P20783
Peptide A residue number
239
Peptide B residue number
152

Ligandability

Cysteine 239 of Brain-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 152 of Neurotrophin-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 141 of Brain-derived neurotrophic factor and cysteine 248 of Neurotrophin-3 (13 and 110 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
1bnd
Structure name
structure of the brain-derived neurotrophic factor(slash)neurotrophin 3 heterodimer
Structure deposition date
1994-12-12
Thiol separation (Å)
9
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide A name
Brain-derived neurotrophic factor
Peptide B name
Neurotrophin-3
Peptide A accession
P23560
Peptide B accession
P20783
Peptide A residue number
141
Peptide B residue number
248

Ligandability

Cysteine 141 of Brain-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 248 of Neurotrophin-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 196 of Brain-derived neurotrophic factor and cysteine 248 of Neurotrophin-3 (68 and 110 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
1bnd
Structure name
structure of the brain-derived neurotrophic factor(slash)neurotrophin 3 heterodimer
Structure deposition date
1994-12-12
Thiol separation (Å)
9
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide A name
Brain-derived neurotrophic factor
Peptide B name
Neurotrophin-3
Peptide A accession
P23560
Peptide B accession
P20783
Peptide A residue number
196
Peptide B residue number
248

Ligandability

Cysteine 196 of Brain-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 248 of Neurotrophin-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 239 of Brain-derived neurotrophic factor and cysteine 205 of Neurotrophin-3 (111 and 67 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
1bnd
Structure name
structure of the brain-derived neurotrophic factor(slash)neurotrophin 3 heterodimer
Structure deposition date
1994-12-12
Thiol separation (Å)
9
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide A name
Brain-derived neurotrophic factor
Peptide B name
Neurotrophin-3
Peptide A accession
P23560
Peptide B accession
P20783
Peptide A residue number
239
Peptide B residue number
205

Ligandability

Cysteine 239 of Brain-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 205 of Neurotrophin-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Brain-derived neurotrophic factor between cysteines 141 and 208 (13 and 80 respectively in this structure).

Details

Redox score ?
86
PDB code
1bnd
Structure name
structure of the brain-derived neurotrophic factor(slash)neurotrophin 3 heterodimer
Structure deposition date
1994-12-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
P23560
Residue number A
141
Residue number B
208
Peptide name
Brain-derived neurotrophic factor

Ligandability

Cysteine 141 of Brain-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 208 of Brain-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Brain-derived neurotrophic factor between cysteines 186 and 237 (58 and 109 respectively in this structure).

Details

Redox score ?
84
PDB code
1bnd
Structure name
structure of the brain-derived neurotrophic factor(slash)neurotrophin 3 heterodimer
Structure deposition date
1994-12-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P23560
Residue number A
186
Residue number B
237
Peptide name
Brain-derived neurotrophic factor

Ligandability

Cysteine 186 of Brain-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 237 of Brain-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Brain-derived neurotrophic factor between cysteines 196 and 239 (68 and 111 respectively in this structure).

Details

Redox score ?
83
PDB code
1bnd
Structure name
structure of the brain-derived neurotrophic factor(slash)neurotrophin 3 heterodimer
Structure deposition date
1994-12-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
P23560
Residue number A
196
Residue number B
239
Peptide name
Brain-derived neurotrophic factor

Ligandability

Cysteine 196 of Brain-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 239 of Brain-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Brain-derived neurotrophic factor between cysteines 196 and 208 (68 and 80 respectively in this structure).

Details

Redox score ?
76
PDB code
1bnd
Structure name
structure of the brain-derived neurotrophic factor(slash)neurotrophin 3 heterodimer
Structure deposition date
1994-12-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
P23560
Residue number A
196
Residue number B
208
Peptide name
Brain-derived neurotrophic factor

Ligandability

Cysteine 196 of Brain-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 208 of Brain-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Brain-derived neurotrophic factor between cysteines 141 and 196 (13 and 68 respectively in this structure).

Details

Redox score ?
73
PDB code
1bnd
Structure name
structure of the brain-derived neurotrophic factor(slash)neurotrophin 3 heterodimer
Structure deposition date
1994-12-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
P23560
Residue number A
141
Residue number B
196
Peptide name
Brain-derived neurotrophic factor

Ligandability

Cysteine 141 of Brain-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 196 of Brain-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Brain-derived neurotrophic factor between cysteines 141 and 237 (13 and 109 respectively in this structure).

Details

Redox score ?
70
PDB code
1bnd
Structure name
structure of the brain-derived neurotrophic factor(slash)neurotrophin 3 heterodimer
Structure deposition date
1994-12-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
P23560
Residue number A
141
Residue number B
237
Peptide name
Brain-derived neurotrophic factor

Ligandability

Cysteine 141 of Brain-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 237 of Brain-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Brain-derived neurotrophic factor between cysteines 208 and 237 (80 and 109 respectively in this structure).

Details

Redox score ?
70
PDB code
1bnd
Structure name
structure of the brain-derived neurotrophic factor(slash)neurotrophin 3 heterodimer
Structure deposition date
1994-12-12
Thiol separation (Å)
5
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
P23560
Residue number A
208
Residue number B
237
Peptide name
Brain-derived neurotrophic factor

Ligandability

Cysteine 208 of Brain-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 237 of Brain-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Brain-derived neurotrophic factor between cysteines 141 and 239 (13 and 111 respectively in this structure).

Details

Redox score ?
68
PDB code
1bnd
Structure name
structure of the brain-derived neurotrophic factor(slash)neurotrophin 3 heterodimer
Structure deposition date
1994-12-12
Thiol separation (Å)
5
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
P23560
Residue number A
141
Residue number B
239
Peptide name
Brain-derived neurotrophic factor

Ligandability

Cysteine 141 of Brain-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 239 of Brain-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Brain-derived neurotrophic factor between cysteines 186 and 208 (58 and 80 respectively in this structure).

Details

Redox score ?
67
PDB code
1bnd
Structure name
structure of the brain-derived neurotrophic factor(slash)neurotrophin 3 heterodimer
Structure deposition date
1994-12-12
Thiol separation (Å)
5
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
P23560
Residue number A
186
Residue number B
208
Peptide name
Brain-derived neurotrophic factor

Ligandability

Cysteine 186 of Brain-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 208 of Brain-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Brain-derived neurotrophic factor between cysteines 208 and 239 (80 and 111 respectively in this structure).

Details

Redox score ?
66
PDB code
1bnd
Structure name
structure of the brain-derived neurotrophic factor(slash)neurotrophin 3 heterodimer
Structure deposition date
1994-12-12
Thiol separation (Å)
5
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
P23560
Residue number A
208
Residue number B
239
Peptide name
Brain-derived neurotrophic factor

Ligandability

Cysteine 208 of Brain-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 239 of Brain-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Brain-derived neurotrophic factor between cysteines 141 and 186 (13 and 58 respectively in this structure).

Details

Redox score ?
64
PDB code
1bnd
Structure name
structure of the brain-derived neurotrophic factor(slash)neurotrophin 3 heterodimer
Structure deposition date
1994-12-12
Thiol separation (Å)
5
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P23560
Residue number A
141
Residue number B
186
Peptide name
Brain-derived neurotrophic factor

Ligandability

Cysteine 141 of Brain-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 186 of Brain-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Brain-derived neurotrophic factor between cysteines 196 and 237 (68 and 109 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
1bnd
Structure name
structure of the brain-derived neurotrophic factor(slash)neurotrophin 3 heterodimer
Structure deposition date
1994-12-12
Thiol separation (Å)
8
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
P23560
Residue number A
196
Residue number B
237
Peptide name
Brain-derived neurotrophic factor

Ligandability

Cysteine 196 of Brain-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 237 of Brain-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Brain-derived neurotrophic factor between cysteines 186 and 196 (58 and 68 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
1bnd
Structure name
structure of the brain-derived neurotrophic factor(slash)neurotrophin 3 heterodimer
Structure deposition date
1994-12-12
Thiol separation (Å)
8
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
P23560
Residue number A
186
Residue number B
196
Peptide name
Brain-derived neurotrophic factor

Ligandability

Cysteine 186 of Brain-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 196 of Brain-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Brain-derived neurotrophic factor between cysteines 237 and 239 (109 and 111 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
1bnd
Structure name
structure of the brain-derived neurotrophic factor(slash)neurotrophin 3 heterodimer
Structure deposition date
1994-12-12
Thiol separation (Å)
9
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
P23560
Residue number A
237
Residue number B
239
Peptide name
Brain-derived neurotrophic factor

Ligandability

Cysteine 237 of Brain-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 239 of Brain-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Brain-derived neurotrophic factor between cysteines 186 and 239 (58 and 111 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
1bnd
Structure name
structure of the brain-derived neurotrophic factor(slash)neurotrophin 3 heterodimer
Structure deposition date
1994-12-12
Thiol separation (Å)
9
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
P23560
Residue number A
186
Residue number B
239
Peptide name
Brain-derived neurotrophic factor

Ligandability

Cysteine 186 of Brain-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 239 of Brain-derived neurotrophic factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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