a tool for identifying drug-targetable redox-active disulphides

C-type natriuretic peptide

Intramolecular

Cysteine 110 and cysteine 126

A redox-regulated disulphide may form within C-type natriuretic peptide between cysteines 110 and 126 (6 and 22 respectively in this structure).

Details

Redox score ?

88

PDB code

Structure name

crystal structure of hormone/receptor complex

Structure deposition date

2001-06-14

Thiol separation (Å)

2

Half-sphere exposure sum ?

nan

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

110

Residue number B

126

Peptide name

C-type natriuretic peptide

Ligandability

Cysteine 110 of C-type natriuretic peptide

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 126 of C-type natriuretic peptide

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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