ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Endothelial transcription factor GATA-2

Intramolecular
Cysteine 349 and cysteine 352
Cysteine 349 and cysteine 373
Cysteine 349 and cysteine 370
Cysteine 352 and cysteine 370
Cysteine 352 and cysteine 373
Cysteine 370 and cysteine 373
Cysteine 348 and cysteine 349
Cysteine 348 and cysteine 352
A redox-regulated disulphide may form within Endothelial transcription factor GATA-2 between cysteines 349 and 352 (7 and 10 respectively in this structure).

Details

Redox score ?
84
PDB code
5o9b
Structure name
solution nmr structure of human gata2 c-terminal zinc finger domain
Structure deposition date
2017-06-16
Thiol separation (Å)
4
Half-sphere exposure sum ?
61
Minimum pKa ?
6
% buried
32
Peptide accession
P23769
Residue number A
349
Residue number B
352
Peptide name
Endothelial transcription factor GATA-2

Ligandability

Cysteine 349 of Endothelial transcription factor GATA-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 352 of Endothelial transcription factor GATA-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Endothelial transcription factor GATA-2 between cysteines 349 and 373 (7 and 31 respectively in this structure).

Details

Redox score ?
81
PDB code
5o9b
Structure name
solution nmr structure of human gata2 c-terminal zinc finger domain
Structure deposition date
2017-06-16
Thiol separation (Å)
4
Half-sphere exposure sum ?
73
Minimum pKa ?
6
% buried
42
Peptide accession
P23769
Residue number A
349
Residue number B
373
Peptide name
Endothelial transcription factor GATA-2

Ligandability

Cysteine 349 of Endothelial transcription factor GATA-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 373 of Endothelial transcription factor GATA-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Endothelial transcription factor GATA-2 between cysteines 349 and 370 (7 and 28 respectively in this structure).

Details

Redox score ?
80
PDB code
5o9b
Structure name
solution nmr structure of human gata2 c-terminal zinc finger domain
Structure deposition date
2017-06-16
Thiol separation (Å)
4
Half-sphere exposure sum ?
74
Minimum pKa ?
6
% buried
44
Peptide accession
P23769
Residue number A
349
Residue number B
370
Peptide name
Endothelial transcription factor GATA-2

Ligandability

Cysteine 349 of Endothelial transcription factor GATA-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 370 of Endothelial transcription factor GATA-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Endothelial transcription factor GATA-2 between cysteines 352 and 370 (10 and 28 respectively in this structure).

Details

Redox score ?
76
PDB code
5o9b
Structure name
solution nmr structure of human gata2 c-terminal zinc finger domain
Structure deposition date
2017-06-16
Thiol separation (Å)
4
Half-sphere exposure sum ?
65
Minimum pKa ?
8
% buried
36
Peptide accession
P23769
Residue number A
352
Residue number B
370
Peptide name
Endothelial transcription factor GATA-2

Ligandability

Cysteine 352 of Endothelial transcription factor GATA-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 370 of Endothelial transcription factor GATA-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Endothelial transcription factor GATA-2 between cysteines 352 and 373 (10 and 31 respectively in this structure).

Details

Redox score ?
74
PDB code
5o9b
Structure name
solution nmr structure of human gata2 c-terminal zinc finger domain
Structure deposition date
2017-06-16
Thiol separation (Å)
4
Half-sphere exposure sum ?
64
Minimum pKa ?
9
% buried
35
Peptide accession
P23769
Residue number A
352
Residue number B
373
Peptide name
Endothelial transcription factor GATA-2

Ligandability

Cysteine 352 of Endothelial transcription factor GATA-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 373 of Endothelial transcription factor GATA-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Endothelial transcription factor GATA-2 between cysteines 370 and 373 (28 and 31 respectively in this structure).

Details

Redox score ?
73
PDB code
5o9b
Structure name
solution nmr structure of human gata2 c-terminal zinc finger domain
Structure deposition date
2017-06-16
Thiol separation (Å)
4
Half-sphere exposure sum ?
77
Minimum pKa ?
8
% buried
46
Peptide accession
P23769
Residue number A
370
Residue number B
373
Peptide name
Endothelial transcription factor GATA-2

Ligandability

Cysteine 370 of Endothelial transcription factor GATA-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 373 of Endothelial transcription factor GATA-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Endothelial transcription factor GATA-2 between cysteines 348 and 349 (6 and 7 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
5o9b
Structure name
solution nmr structure of human gata2 c-terminal zinc finger domain
Structure deposition date
2017-06-16
Thiol separation (Å)
8
Half-sphere exposure sum ?
62
Minimum pKa ?
6
% buried
20
Peptide accession
P23769
Residue number A
348
Residue number B
349
Peptide name
Endothelial transcription factor GATA-2

Ligandability

Cysteine 348 of Endothelial transcription factor GATA-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 349 of Endothelial transcription factor GATA-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Endothelial transcription factor GATA-2 between cysteines 348 and 352 (6 and 10 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
5o9b
Structure name
solution nmr structure of human gata2 c-terminal zinc finger domain
Structure deposition date
2017-06-16
Thiol separation (Å)
10
Half-sphere exposure sum ?
53
Minimum pKa ?
9
% buried
12
Peptide accession
P23769
Residue number A
348
Residue number B
352
Peptide name
Endothelial transcription factor GATA-2

Ligandability

Cysteine 348 of Endothelial transcription factor GATA-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 352 of Endothelial transcription factor GATA-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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