Trans-acting T-cell-specific transcription factor GATA-3
Intramolecular
Cysteine 317 and cysteine 341
Cysteine 263 and cysteine 266
Cysteine 317 and cysteine 320
Cysteine 320 and cysteine 338
Cysteine 263 and cysteine 287
Cysteine 338 and cysteine 341
Cysteine 266 and cysteine 287
Cysteine 320 and cysteine 341
Cysteine 266 and cysteine 284
Cysteine 284 and cysteine 287
More...Cysteine 263 and cysteine 284
Cysteine 317 and cysteine 338
3dfx A 317 A 341
A redox-regulated disulphide may form within Trans-acting T-cell-specific transcription factor GATA-3 between cysteines 317 and 341.
Details
Redox score ?
95
PDB code
3dfx
Structure name
opposite gata dna binding
Structure deposition date
2008-06-12
Thiol separation (Å)
3
Half-sphere exposure sum ?
65
Minimum pKa ?
1
% buried
52
Peptide accession
P23772
Residue number A
317
Residue number B
341
Peptide name
Trans-acting T-cell-specific transcription factor GATA-3
Ligandability
Cysteine 317 of Trans-acting T-cell-specific transcription factor GATA-3
Cysteine 341 of Trans-acting T-cell-specific transcription factor GATA-3
4hc7 A 264 A 267
A redox-regulated disulphide may form within Trans-acting T-cell-specific transcription factor GATA-3 between cysteines 263 and 266 (264 and 267 respectively in this structure).
Details
Redox score ?
85
PDB code
4hc7
Structure name
crystal structure of the full dna binding domain of gata3-complex 2
Structure deposition date
2012-09-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
57
Minimum pKa ?
5
% buried
22
Peptide accession
P23771
Residue number A
263
Residue number B
266
Peptide name
Trans-acting T-cell-specific transcription factor GATA-3
Ligandability
Cysteine 263 of Trans-acting T-cell-specific transcription factor GATA-3
Cysteine 266 of Trans-acting T-cell-specific transcription factor GATA-3
3dfv D 317 D 320
A redox-regulated disulphide may form within Trans-acting T-cell-specific transcription factor GATA-3 between cysteines 317 and 320.
Details
Redox score ?
83
PDB code
3dfv
Structure name
adjacent gata dna binding
Structure deposition date
2008-06-12
Thiol separation (Å)
3
Half-sphere exposure sum ?
60
Minimum pKa ?
7
% buried
nan
Peptide accession
P23772
Residue number A
317
Residue number B
320
Peptide name
Trans-acting T-cell-specific transcription factor GATA-3
Ligandability
Cysteine 317 of Trans-acting T-cell-specific transcription factor GATA-3
Cysteine 320 of Trans-acting T-cell-specific transcription factor GATA-3
3dfv D 320 D 338
A redox-regulated disulphide may form within Trans-acting T-cell-specific transcription factor GATA-3 between cysteines 320 and 338.
Details
Redox score ?
83
PDB code
3dfv
Structure name
adjacent gata dna binding
Structure deposition date
2008-06-12
Thiol separation (Å)
3
Half-sphere exposure sum ?
62
Minimum pKa ?
7
% buried
54
Peptide accession
P23772
Residue number A
320
Residue number B
338
Peptide name
Trans-acting T-cell-specific transcription factor GATA-3
Ligandability
Cysteine 320 of Trans-acting T-cell-specific transcription factor GATA-3
Cysteine 338 of Trans-acting T-cell-specific transcription factor GATA-3
4hca A 264 A 288
A redox-regulated disulphide may form within Trans-acting T-cell-specific transcription factor GATA-3 between cysteines 263 and 287 (264 and 288 respectively in this structure).
Details
Redox score ?
81
PDB code
4hca
Structure name
dna binding by gata transcription factor-complex 1
Structure deposition date
2012-09-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
64
Minimum pKa ?
6
% buried
33
Peptide accession
P23771
Residue number A
263
Residue number B
287
Peptide name
Trans-acting T-cell-specific transcription factor GATA-3
Ligandability
Cysteine 263 of Trans-acting T-cell-specific transcription factor GATA-3
Cysteine 287 of Trans-acting T-cell-specific transcription factor GATA-3
4hc7 B 339 B 342
A redox-regulated disulphide may form within Trans-acting T-cell-specific transcription factor GATA-3 between cysteines 338 and 341 (339 and 342 respectively in this structure).
Details
Redox score ?
77
PDB code
4hc7
Structure name
crystal structure of the full dna binding domain of gata3-complex 2
Structure deposition date
2012-09-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
67
Minimum pKa ?
7
% buried
61
Peptide accession
P23771
Residue number A
338
Residue number B
341
Peptide name
Trans-acting T-cell-specific transcription factor GATA-3
Ligandability
Cysteine 338 of Trans-acting T-cell-specific transcription factor GATA-3
Cysteine 341 of Trans-acting T-cell-specific transcription factor GATA-3
4hc7 A 267 A 288
A redox-regulated disulphide may form within Trans-acting T-cell-specific transcription factor GATA-3 between cysteines 266 and 287 (267 and 288 respectively in this structure).
Details
Redox score ?
76
PDB code
4hc7
Structure name
crystal structure of the full dna binding domain of gata3-complex 2
Structure deposition date
2012-09-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
62
Minimum pKa ?
8
% buried
25
Peptide accession
P23771
Residue number A
266
Residue number B
287
Peptide name
Trans-acting T-cell-specific transcription factor GATA-3
Ligandability
Cysteine 266 of Trans-acting T-cell-specific transcription factor GATA-3
Cysteine 287 of Trans-acting T-cell-specific transcription factor GATA-3
4hc9 A 321 A 342
A redox-regulated disulphide may form within Trans-acting T-cell-specific transcription factor GATA-3 between cysteines 320 and 341 (321 and 342 respectively in this structure).
Details
Redox score ?
74
PDB code
4hc9
Structure name
dna binding by gata transcription factor-complex 3
Structure deposition date
2012-09-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
64
Minimum pKa ?
10
% buried
28
Peptide accession
P23771
Residue number A
320
Residue number B
341
Peptide name
Trans-acting T-cell-specific transcription factor GATA-3
Ligandability
Cysteine 320 of Trans-acting T-cell-specific transcription factor GATA-3
Cysteine 341 of Trans-acting T-cell-specific transcription factor GATA-3
4hc7 B 267 B 285
A redox-regulated disulphide may form within Trans-acting T-cell-specific transcription factor GATA-3 between cysteines 266 and 284 (267 and 285 respectively in this structure).
Details
Redox score ?
71
PDB code
4hc7
Structure name
crystal structure of the full dna binding domain of gata3-complex 2
Structure deposition date
2012-09-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
8
% buried
53
Peptide accession
P23771
Residue number A
266
Residue number B
284
Peptide name
Trans-acting T-cell-specific transcription factor GATA-3
Ligandability
Cysteine 266 of Trans-acting T-cell-specific transcription factor GATA-3
Cysteine 284 of Trans-acting T-cell-specific transcription factor GATA-3
4hc7 B 285 B 288
A redox-regulated disulphide may form within Trans-acting T-cell-specific transcription factor GATA-3 between cysteines 284 and 287 (285 and 288 respectively in this structure).
Details
Redox score ?
70
PDB code
4hc7
Structure name
crystal structure of the full dna binding domain of gata3-complex 2
Structure deposition date
2012-09-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
67
Minimum pKa ?
10
% buried
65
Peptide accession
P23771
Residue number A
284
Residue number B
287
Peptide name
Trans-acting T-cell-specific transcription factor GATA-3
Ligandability
Cysteine 284 of Trans-acting T-cell-specific transcription factor GATA-3
Cysteine 287 of Trans-acting T-cell-specific transcription factor GATA-3
4hc7 B 264 B 285
A redox-regulated disulphide may form within Trans-acting T-cell-specific transcription factor GATA-3 between cysteines 263 and 284 (264 and 285 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
4hc7
Structure name
crystal structure of the full dna binding domain of gata3-complex 2
Structure deposition date
2012-09-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
65
Minimum pKa ?
19
% buried
nan
Peptide accession
P23771
Residue number A
263
Residue number B
284
Peptide name
Trans-acting T-cell-specific transcription factor GATA-3
Ligandability
Cysteine 263 of Trans-acting T-cell-specific transcription factor GATA-3
Cysteine 284 of Trans-acting T-cell-specific transcription factor GATA-3
3dfv C 317 C 338
A redox-regulated disulphide may form within Trans-acting T-cell-specific transcription factor GATA-3 between cysteines 317 and 338. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
51
PDB code
3dfv
Structure name
adjacent gata dna binding
Structure deposition date
2008-06-12
Thiol separation (Å)
3
Half-sphere exposure sum ?
64
Minimum pKa ?
22
% buried
nan
Peptide accession
P23772
Residue number A
317
Residue number B
338
Peptide name
Trans-acting T-cell-specific transcription factor GATA-3
Ligandability
Cysteine 317 of Trans-acting T-cell-specific transcription factor GATA-3
Cysteine 338 of Trans-acting T-cell-specific transcription factor GATA-3
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