ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Myeloblastin

Intramolecular
Cysteine 152 and cysteine 209
Cysteine 182 and cysteine 188
Cysteine 199 and cysteine 224
Cysteine 56 and cysteine 72
A redox-regulated disulphide may form within Myeloblastin between cysteines 152 and 209 (136 and 201 respectively in this structure).

Details

Redox score ?
85
PDB code
1fuj
Structure name
pr3 (myeloblastin)
Structure deposition date
1996-01-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P24158
Residue number A
152
Residue number B
209
Peptide name
Myeloblastin

Ligandability

Cysteine 152 of Myeloblastin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 209 of Myeloblastin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Myeloblastin between cysteines 182 and 188 (168 and 182 respectively in this structure).

Details

Redox score ?
83
PDB code
1fuj
Structure name
pr3 (myeloblastin)
Structure deposition date
1996-01-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P24158
Residue number A
182
Residue number B
188
Peptide name
Myeloblastin

Ligandability

Cysteine 182 of Myeloblastin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 188 of Myeloblastin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Myeloblastin between cysteines 199 and 224 (191 and 220 respectively in this structure).

Details

Redox score ?
79
PDB code
1fuj
Structure name
pr3 (myeloblastin)
Structure deposition date
1996-01-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
P24158
Residue number A
199
Residue number B
224
Peptide name
Myeloblastin

Ligandability

Cysteine 199 of Myeloblastin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 224 of Myeloblastin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Myeloblastin between cysteines 56 and 72 (42 and 58 respectively in this structure).

Details

Redox score ?
79
PDB code
1fuj
Structure name
pr3 (myeloblastin)
Structure deposition date
1996-01-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
86
Minimum pKa ?
nan
% buried
nan
Peptide accession
P24158
Residue number A
56
Residue number B
72
Peptide name
Myeloblastin

Ligandability

Cysteine 56 of Myeloblastin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 72 of Myeloblastin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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