Interleukin-4 receptor subunit alpha
Intramolecular
Cysteine 54 and cysteine 84
Cysteine 34 and cysteine 44
Cysteine 74 and cysteine 86
Cysteine 44 and cysteine 86
Cysteine 44 and cysteine 74
Cysteine 54 and cysteine 86
Cysteine 34 and cysteine 74
Cysteine 84 and cysteine 86
Cysteine 34 and cysteine 86
6oel B 29 B 59
A redox-regulated disulphide may form within Interleukin-4 receptor subunit alpha between cysteines 54 and 84 (29 and 59 respectively in this structure).
Details
Redox score ?
86
PDB code
6oel
Structure name
engineered fab bound to il-4 receptor
Structure deposition date
2019-03-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P24394
Residue number A
54
Residue number B
84
Peptide name
Interleukin-4 receptor subunit alpha
Ligandability
Cysteine 54 of Interleukin-4 receptor subunit alpha
Cysteine 84 of Interleukin-4 receptor subunit alpha
1iar B 9 B 19
A redox-regulated disulphide may form within Interleukin-4 receptor subunit alpha between cysteines 34 and 44 (9 and 19 respectively in this structure).
Details
Redox score ?
85
PDB code
1iar
Structure name
interleukin-4 / receptor alpha chain complex
Structure deposition date
1999-02-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P24394
Residue number A
34
Residue number B
44
Peptide name
Interleukin-4 receptor subunit alpha
Ligandability
Cysteine 34 of Interleukin-4 receptor subunit alpha
Cysteine 44 of Interleukin-4 receptor subunit alpha
6wgl C 49 C 61
A redox-regulated disulphide may form within Interleukin-4 receptor subunit alpha between cysteines 74 and 86 (49 and 61 respectively in this structure).
Details
Redox score ?
82
PDB code
6wgl
Structure name
dupilumab fab with crystal kappa design complexed with human il-4 receptor
Structure deposition date
2020-04-05
Thiol separation (Å)
3
Half-sphere exposure sum ?
62
Minimum pKa ?
7
% buried
56
Peptide accession
P24394
Residue number A
74
Residue number B
86
Peptide name
Interleukin-4 receptor subunit alpha
Ligandability
Cysteine 74 of Interleukin-4 receptor subunit alpha
Cysteine 86 of Interleukin-4 receptor subunit alpha
5e4e B 19 B 61
A redox-regulated disulphide may form within Interleukin-4 receptor subunit alpha between cysteines 44 and 86 (19 and 61 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
58
PDB code
5e4e
Structure name
engineered interleukin-13 bound to receptor
Structure deposition date
2015-10-05
Thiol separation (Å)
6
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
P24394
Residue number A
44
Residue number B
86
Peptide name
Interleukin-4 receptor subunit alpha
Ligandability
Cysteine 44 of Interleukin-4 receptor subunit alpha
Cysteine 86 of Interleukin-4 receptor subunit alpha
3bpo B 19 B 49
A redox-regulated disulphide may form within Interleukin-4 receptor subunit alpha between cysteines 44 and 74 (19 and 49 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
3bpo
Structure name
crystal structure of the il13-il4r-il13ra ternary complex
Structure deposition date
2007-12-18
Thiol separation (Å)
8
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P24394
Residue number A
44
Residue number B
74
Peptide name
Interleukin-4 receptor subunit alpha
Ligandability
Cysteine 44 of Interleukin-4 receptor subunit alpha
Cysteine 74 of Interleukin-4 receptor subunit alpha
1iar B 29 B 61
A redox-regulated disulphide may form within Interleukin-4 receptor subunit alpha between cysteines 54 and 86 (29 and 61 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
1iar
Structure name
interleukin-4 / receptor alpha chain complex
Structure deposition date
1999-02-25
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P24394
Residue number A
54
Residue number B
86
Peptide name
Interleukin-4 receptor subunit alpha
Ligandability
Cysteine 54 of Interleukin-4 receptor subunit alpha
Cysteine 86 of Interleukin-4 receptor subunit alpha
3bpo B 9 B 49
A redox-regulated disulphide may form within Interleukin-4 receptor subunit alpha between cysteines 34 and 74 (9 and 49 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
3bpo
Structure name
crystal structure of the il13-il4r-il13ra ternary complex
Structure deposition date
2007-12-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P24394
Residue number A
34
Residue number B
74
Peptide name
Interleukin-4 receptor subunit alpha
Ligandability
Cysteine 34 of Interleukin-4 receptor subunit alpha
Cysteine 74 of Interleukin-4 receptor subunit alpha
1iar B 59 B 61
A redox-regulated disulphide may form within Interleukin-4 receptor subunit alpha between cysteines 84 and 86 (59 and 61 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
1iar
Structure name
interleukin-4 / receptor alpha chain complex
Structure deposition date
1999-02-25
Thiol separation (Å)
9
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
P24394
Residue number A
84
Residue number B
86
Peptide name
Interleukin-4 receptor subunit alpha
Ligandability
Cysteine 84 of Interleukin-4 receptor subunit alpha
Cysteine 86 of Interleukin-4 receptor subunit alpha
6wgl C 9 C 61
A redox-regulated disulphide may form within Interleukin-4 receptor subunit alpha between cysteines 34 and 86 (9 and 61 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
32
PDB code
6wgl
Structure name
dupilumab fab with crystal kappa design complexed with human il-4 receptor
Structure deposition date
2020-04-05
Thiol separation (Å)
9
Half-sphere exposure sum ?
65
Minimum pKa ?
16
% buried
nan
Peptide accession
P24394
Residue number A
34
Residue number B
86
Peptide name
Interleukin-4 receptor subunit alpha
Ligandability
Cysteine 34 of Interleukin-4 receptor subunit alpha
Cysteine 86 of Interleukin-4 receptor subunit alpha
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