Growth arrest and DNA damage-inducible protein GADD45 alpha
Intramolecular
Cysteine 82 and cysteine 83
Cysteine 57 and cysteine 124
Cysteine 57 and cysteine 82
Cysteine 82 and cysteine 124
Cysteine 145 and cysteine 147
Cysteine 57 and cysteine 83
2kg4 A 82 A 83
A redox-regulated disulphide may form within Growth arrest and DNA damage-inducible protein GADD45 alpha between cysteines 82 and 83.
Details
Redox score ?
73
PDB code
2kg4
Structure name
three-dimensional structure of human gadd45alpha in solution by nmr
Structure deposition date
2009-03-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
54
Minimum pKa ?
9
% buried
36
Peptide accession
P24522
Residue number A
82
Residue number B
83
Peptide name
Growth arrest and DNA damage-inducible protein GADD45 alpha
Ligandability
Cysteine 82 of Growth arrest and DNA damage-inducible protein GADD45 alpha
Cysteine 83 of Growth arrest and DNA damage-inducible protein GADD45 alpha
2kg4 A 57 A 124
A redox-regulated disulphide may form within Growth arrest and DNA damage-inducible protein GADD45 alpha between cysteines 57 and 124.
Details
Redox score ?
67
PDB code
2kg4
Structure name
three-dimensional structure of human gadd45alpha in solution by nmr
Structure deposition date
2009-03-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
80
Minimum pKa ?
11
% buried
89
Peptide accession
P24522
Residue number A
57
Residue number B
124
Peptide name
Growth arrest and DNA damage-inducible protein GADD45 alpha
Ligandability
Cysteine 57 of Growth arrest and DNA damage-inducible protein GADD45 alpha
Cysteine 124 of Growth arrest and DNA damage-inducible protein GADD45 alpha
2kg4 A 57 A 82
A redox-regulated disulphide may form within Growth arrest and DNA damage-inducible protein GADD45 alpha between cysteines 57 and 82. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
55
PDB code
2kg4
Structure name
three-dimensional structure of human gadd45alpha in solution by nmr
Structure deposition date
2009-03-04
Thiol separation (Å)
7
Half-sphere exposure sum ?
76
Minimum pKa ?
9
% buried
74
Peptide accession
P24522
Residue number A
57
Residue number B
82
Peptide name
Growth arrest and DNA damage-inducible protein GADD45 alpha
Ligandability
Cysteine 57 of Growth arrest and DNA damage-inducible protein GADD45 alpha
Cysteine 82 of Growth arrest and DNA damage-inducible protein GADD45 alpha
2kg4 A 82 A 124
A redox-regulated disulphide may form within Growth arrest and DNA damage-inducible protein GADD45 alpha between cysteines 82 and 124. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
2kg4
Structure name
three-dimensional structure of human gadd45alpha in solution by nmr
Structure deposition date
2009-03-04
Thiol separation (Å)
7
Half-sphere exposure sum ?
70
Minimum pKa ?
9
% buried
74
Peptide accession
P24522
Residue number A
82
Residue number B
124
Peptide name
Growth arrest and DNA damage-inducible protein GADD45 alpha
Ligandability
Cysteine 82 of Growth arrest and DNA damage-inducible protein GADD45 alpha
Cysteine 124 of Growth arrest and DNA damage-inducible protein GADD45 alpha
2kg4 A 145 A 147
A redox-regulated disulphide may form within Growth arrest and DNA damage-inducible protein GADD45 alpha between cysteines 145 and 147. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
2kg4
Structure name
three-dimensional structure of human gadd45alpha in solution by nmr
Structure deposition date
2009-03-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
58
Minimum pKa ?
10
% buried
31
Peptide accession
P24522
Residue number A
145
Residue number B
147
Peptide name
Growth arrest and DNA damage-inducible protein GADD45 alpha
Ligandability
Cysteine 145 of Growth arrest and DNA damage-inducible protein GADD45 alpha
Cysteine 147 of Growth arrest and DNA damage-inducible protein GADD45 alpha
2kg4 A 57 A 83
A redox-regulated disulphide may form within Growth arrest and DNA damage-inducible protein GADD45 alpha between cysteines 57 and 83. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
2kg4
Structure name
three-dimensional structure of human gadd45alpha in solution by nmr
Structure deposition date
2009-03-04
Thiol separation (Å)
10
Half-sphere exposure sum ?
64
Minimum pKa ?
10
% buried
52
Peptide accession
P24522
Residue number A
57
Residue number B
83
Peptide name
Growth arrest and DNA damage-inducible protein GADD45 alpha
Ligandability
Cysteine 57 of Growth arrest and DNA damage-inducible protein GADD45 alpha
Cysteine 83 of Growth arrest and DNA damage-inducible protein GADD45 alpha
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