ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Insulin-like growth factor-binding protein 5

Intramolecular
Cysteine 74 and cysteine 100
Cysteine 67 and cysteine 80
Cysteine 67 and cysteine 74
Cysteine 67 and cysteine 100
Cysteine 74 and cysteine 80
Cysteine 80 and cysteine 100
A redox-regulated disulphide may form within Insulin-like growth factor-binding protein 5 between cysteines 74 and 100 (54 and 80 respectively in this structure).

Details

Redox score ?
87
PDB code
1h59
Structure name
complex of igfbp-5 with igf-i
Structure deposition date
2001-05-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
P24593
Residue number A
74
Residue number B
100
Peptide name
Insulin-like growth factor-binding protein 5

Ligandability

Cysteine 74 of Insulin-like growth factor-binding protein 5

Cysteine 100 of Insulin-like growth factor-binding protein 5

A redox-regulated disulphide may form within Insulin-like growth factor-binding protein 5 between cysteines 67 and 80 (47 and 60 respectively in this structure).

Details

Redox score ?
84
PDB code
1h59
Structure name
complex of igfbp-5 with igf-i
Structure deposition date
2001-05-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P24593
Residue number A
67
Residue number B
80
Peptide name
Insulin-like growth factor-binding protein 5

Ligandability

Cysteine 67 of Insulin-like growth factor-binding protein 5

Cysteine 80 of Insulin-like growth factor-binding protein 5

A redox-regulated disulphide may form within Insulin-like growth factor-binding protein 5 between cysteines 67 and 74 (47 and 54 respectively in this structure).

Details

Redox score ?
76
PDB code
1h59
Structure name
complex of igfbp-5 with igf-i
Structure deposition date
2001-05-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P24593
Residue number A
67
Residue number B
74
Peptide name
Insulin-like growth factor-binding protein 5

Ligandability

Cysteine 67 of Insulin-like growth factor-binding protein 5

Cysteine 74 of Insulin-like growth factor-binding protein 5

A redox-regulated disulphide may form within Insulin-like growth factor-binding protein 5 between cysteines 67 and 100 (47 and 80 respectively in this structure).

Details

Redox score ?
74
PDB code
1h59
Structure name
complex of igfbp-5 with igf-i
Structure deposition date
2001-05-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P24593
Residue number A
67
Residue number B
100
Peptide name
Insulin-like growth factor-binding protein 5

Ligandability

Cysteine 67 of Insulin-like growth factor-binding protein 5

Cysteine 100 of Insulin-like growth factor-binding protein 5

A redox-regulated disulphide may form within Insulin-like growth factor-binding protein 5 between cysteines 74 and 80 (54 and 60 respectively in this structure).

Details

Redox score ?
71
PDB code
1h59
Structure name
complex of igfbp-5 with igf-i
Structure deposition date
2001-05-21
Thiol separation (Å)
5
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P24593
Residue number A
74
Residue number B
80
Peptide name
Insulin-like growth factor-binding protein 5

Ligandability

Cysteine 74 of Insulin-like growth factor-binding protein 5

Cysteine 80 of Insulin-like growth factor-binding protein 5

A redox-regulated disulphide may form within Insulin-like growth factor-binding protein 5 between cysteines 80 and 100 (60 and 80 respectively in this structure).

Details

Redox score ?
65
PDB code
1h59
Structure name
complex of igfbp-5 with igf-i
Structure deposition date
2001-05-21
Thiol separation (Å)
6
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
P24593
Residue number A
80
Residue number B
100
Peptide name
Insulin-like growth factor-binding protein 5

Ligandability

Cysteine 80 of Insulin-like growth factor-binding protein 5

Cysteine 100 of Insulin-like growth factor-binding protein 5

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