ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Protein kinase C eta type

Intramolecular
Cysteine 421 and cysteine 422
Cysteine 399 and cysteine 501 L
A redox-regulated disulphide may form within Protein kinase C eta type between cysteines 421 and 422. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
3txo
Structure name
pkc eta kinase in complex with a naphthyridine
Structure deposition date
2011-09-23
Thiol separation (Å)
7
Half-sphere exposure sum ?
62
Minimum pKa ?
11
% buried
68
Peptide accession
P24723
Residue number A
421
Residue number B
422
Peptide name
Protein kinase C eta type

Ligandability

Cysteine 421 of Protein kinase C eta type

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 422 of Protein kinase C eta type

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein kinase C eta type between cysteines 399 and 501. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
3txo
Structure name
pkc eta kinase in complex with a naphthyridine
Structure deposition date
2011-09-23
Thiol separation (Å)
9
Half-sphere exposure sum ?
58
Minimum pKa ?
10
% buried
60
Peptide accession
P24723
Residue number A
399
Residue number B
501
Peptide name
Protein kinase C eta type

Ligandability

Cysteine 399 of Protein kinase C eta type

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 501 of Protein kinase C eta type

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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