ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Deoxyribonuclease-1

Intramolecular
Cysteine 123 and cysteine 126
Cysteine 195 and cysteine 231
A redox-regulated disulphide may form within Deoxyribonuclease-1 between cysteines 123 and 126 (101 and 104 respectively in this structure).

Details

Redox score ?
88
PDB code
4awn
Structure name
structure of recombinant human dnase i (rhdnasei) in complex with magnesium and phosphate
Structure deposition date
2012-06-04
Thiol separation (Å)
3
Half-sphere exposure sum ?
24
Minimum pKa ?
8
% buried
0
Peptide accession
P24855
Residue number A
123
Residue number B
126
Peptide name
Deoxyribonuclease-1

Ligandability

Cysteine 123 of Deoxyribonuclease-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 126 of Deoxyribonuclease-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Deoxyribonuclease-1 between cysteines 195 and 231 (173 and 209 respectively in this structure).

Details

Redox score ?
82
PDB code
4awn
Structure name
structure of recombinant human dnase i (rhdnasei) in complex with magnesium and phosphate
Structure deposition date
2012-06-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P24855
Residue number A
195
Residue number B
231
Peptide name
Deoxyribonuclease-1

Ligandability

Cysteine 195 of Deoxyribonuclease-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 231 of Deoxyribonuclease-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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