ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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DNA replication licensing factor MCM3

Intermolecular
Cysteine 243 and cysteine 219 of DNA replication licensing factor MCM5
Cysteine 243 and cysteine 221 of DNA replication licensing factor MCM5
A redox-regulated disulphide may form between cysteine 243 of DNA replication licensing factor MCM3 and cysteine 219 of DNA replication licensing factor MCM5 (288 and 219 respectively in this structure).

Details

Redox score ?
85
PDB code
6xtx
Structure name
cryoem structure of human cmg bound to atpgammas and dna
Structure deposition date
2020-01-16
Thiol separation (Å)
3
Half-sphere exposure sum ?
70
Minimum pKa ?
4
% buried
80
Peptide A name
DNA replication licensing factor MCM3
Peptide B name
DNA replication licensing factor MCM5
Peptide A accession
P25205
Peptide B accession
P33992
Peptide A residue number
243
Peptide B residue number
219

Ligandability

Cysteine 243 of DNA replication licensing factor MCM3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 219 of DNA replication licensing factor MCM5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 243 of DNA replication licensing factor MCM3 and cysteine 221 of DNA replication licensing factor MCM5 (288 and 221 respectively in this structure).

Details

Redox score ?
81
PDB code
6xty
Structure name
cryoem structure of human cmg bound to and-1 (cmga)
Structure deposition date
2020-01-16
Thiol separation (Å)
4
Half-sphere exposure sum ?
76
Minimum pKa ?
4
% buried
76
Peptide A name
DNA replication licensing factor MCM3
Peptide B name
DNA replication licensing factor MCM5
Peptide A accession
P25205
Peptide B accession
P33992
Peptide A residue number
243
Peptide B residue number
221

Ligandability

Cysteine 243 of DNA replication licensing factor MCM3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 221 of DNA replication licensing factor MCM5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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