ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Zinc-alpha-2-glycoprotein

Intramolecular
Cysteine 225 and cysteine 280
Cysteine 123 and cysteine 186
A redox-regulated disulphide may form within Zinc-alpha-2-glycoprotein between cysteines 225 and 280 (205 and 260 respectively in this structure).

Details

Redox score ?
81
PDB code
6r2u
Structure name
zinc-alpha2-glycoprotein with a fluorescent dansyl c 11 fatty acid
Structure deposition date
2019-03-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
P25311
Residue number A
225
Residue number B
280
Peptide name
Zinc-alpha-2-glycoprotein

Ligandability

Cysteine 225 of Zinc-alpha-2-glycoprotein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 280 of Zinc-alpha-2-glycoprotein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zinc-alpha-2-glycoprotein between cysteines 123 and 186 (103 and 166 respectively in this structure).

Details

Redox score ?
78
PDB code
1t7y
Structure name
zn-alpha-2-glycoprotein; baculo-zag peg 200, no glycerol
Structure deposition date
2004-05-11
Thiol separation (Å)
3
Half-sphere exposure sum ?
66
Minimum pKa ?
8
% buried
73
Peptide accession
P25311
Residue number A
123
Residue number B
186
Peptide name
Zinc-alpha-2-glycoprotein

Ligandability

Cysteine 123 of Zinc-alpha-2-glycoprotein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 186 of Zinc-alpha-2-glycoprotein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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