40S ribosomal protein S12
Intramolecular
Cysteine 50 and cysteine 108 L
Cysteine 50 and cysteine 69 L
Cysteine 69 and cysteine 108 L
Cysteine 106 and cysteine 108 L
Cysteine 56 and cysteine 106 L
Cysteine 92 and cysteine 106 L
Cysteine 56 and cysteine 108 L
Cysteine 50 and cysteine 106 L
7k5i M 50 M 108
A redox-regulated disulphide may form within 40S ribosomal protein S12 between cysteines 50 and 108.
Details
Redox score ?
65
PDB code
7k5i
Structure name
sars-cov-2 nsp1 in complex with human 40s ribosome
Structure deposition date
2020-09-16
Thiol separation (Å)
4
Half-sphere exposure sum ?
81
Minimum pKa ?
9
% buried
96
Peptide accession
P25398
Residue number A
50
Residue number B
108
Peptide name
40S ribosomal protein S12
Ligandability
Cysteine 50 of 40S ribosomal protein S12
Cysteine 108 of 40S ribosomal protein S12
7k5i M 50 M 69
A redox-regulated disulphide may form within 40S ribosomal protein S12 between cysteines 50 and 69.
Details
Redox score ?
64
PDB code
7k5i
Structure name
sars-cov-2 nsp1 in complex with human 40s ribosome
Structure deposition date
2020-09-16
Thiol separation (Å)
4
Half-sphere exposure sum ?
71
Minimum pKa ?
14
% buried
80
Peptide accession
P25398
Residue number A
50
Residue number B
69
Peptide name
40S ribosomal protein S12
Ligandability
Cysteine 50 of 40S ribosomal protein S12
Cysteine 69 of 40S ribosomal protein S12
7wtx M 69 M 108
A redox-regulated disulphide may form within 40S ribosomal protein S12 between cysteines 69 and 108. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
51
PDB code
7wtx
Structure name
cryo-em structure of a human pre-40s ribosomal subunit - state rrp12- b1
Structure deposition date
2022-02-05
Thiol separation (Å)
7
Half-sphere exposure sum ?
70
Minimum pKa ?
9
% buried
74
Peptide accession
P25398
Residue number A
69
Residue number B
108
Peptide name
40S ribosomal protein S12
Ligandability
Cysteine 69 of 40S ribosomal protein S12
Cysteine 108 of 40S ribosomal protein S12
7wtx M 106 M 108
A redox-regulated disulphide may form within 40S ribosomal protein S12 between cysteines 106 and 108. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
7wtx
Structure name
cryo-em structure of a human pre-40s ribosomal subunit - state rrp12- b1
Structure deposition date
2022-02-05
Thiol separation (Å)
7
Half-sphere exposure sum ?
77
Minimum pKa ?
9
% buried
100
Peptide accession
P25398
Residue number A
106
Residue number B
108
Peptide name
40S ribosomal protein S12
Ligandability
Cysteine 106 of 40S ribosomal protein S12
Cysteine 108 of 40S ribosomal protein S12
7wtv M 56 M 106
A redox-regulated disulphide may form within 40S ribosomal protein S12 between cysteines 56 and 106. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
7wtv
Structure name
cryo-em structure of a human pre-40s ribosomal subunit - state rrp12- a2
Structure deposition date
2022-02-05
Thiol separation (Å)
10
Half-sphere exposure sum ?
56
Minimum pKa ?
10
% buried
68
Peptide accession
P25398
Residue number A
56
Residue number B
106
Peptide name
40S ribosomal protein S12
Ligandability
Cysteine 56 of 40S ribosomal protein S12
Cysteine 106 of 40S ribosomal protein S12
7wtu M 92 M 106
A redox-regulated disulphide may form within 40S ribosomal protein S12 between cysteines 92 and 106. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
7wtu
Structure name
cryo-em structure of a human pre-40s ribosomal subunit - state rrp12- a1 (without ck1)
Structure deposition date
2022-02-05
Thiol separation (Å)
10
Half-sphere exposure sum ?
54
Minimum pKa ?
10
% buried
68
Peptide accession
P25398
Residue number A
92
Residue number B
106
Peptide name
40S ribosomal protein S12
Ligandability
Cysteine 92 of 40S ribosomal protein S12
Cysteine 106 of 40S ribosomal protein S12
5oa3 M 56 M 108
A redox-regulated disulphide may form within 40S ribosomal protein S12 between cysteines 56 and 108. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
5oa3
Structure name
human 40s-eif2d-re-initiation complex
Structure deposition date
2017-06-20
Thiol separation (Å)
10
Half-sphere exposure sum ?
63
Minimum pKa ?
10
% buried
56
Peptide accession
P25398
Residue number A
56
Residue number B
108
Peptide name
40S ribosomal protein S12
Ligandability
Cysteine 56 of 40S ribosomal protein S12
Cysteine 108 of 40S ribosomal protein S12
5flx M 50 M 106
A redox-regulated disulphide may form within 40S ribosomal protein S12 between cysteines 50 and 106. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
30
PDB code
5flx
Structure name
mammalian 40s hcv-ires complex
Structure deposition date
2015-10-28
Thiol separation (Å)
10
Half-sphere exposure sum ?
78
Minimum pKa ?
11
% buried
96
Peptide accession
P25398
Residue number A
50
Residue number B
106
Peptide name
40S ribosomal protein S12
Ligandability
Cysteine 50 of 40S ribosomal protein S12
Cysteine 106 of 40S ribosomal protein S12
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