ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Transcriptional repressor protein YY1

Intramolecular
Cysteine 327 and cysteine 330
Cysteine 385 and cysteine 390
Cysteine 355 and cysteine 360
Cysteine 298 and cysteine 303
A redox-regulated disulphide may form within Transcriptional repressor protein YY1 between cysteines 327 and 330.

Details

Redox score ?
91
PDB code
1ubd
Structure name
co-crystal structure of human yy1 zinc finger domain bound to the adeno-associated virus p5 initiator element
Structure deposition date
1996-10-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
37
Minimum pKa ?
5
% buried
0
Peptide accession
P25490
Residue number A
327
Residue number B
330
Peptide name
Transcriptional repressor protein YY1

Ligandability

Cysteine 327 of Transcriptional repressor protein YY1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 330 of Transcriptional repressor protein YY1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcriptional repressor protein YY1 between cysteines 385 and 390.

Details

Redox score ?
89
PDB code
1ubd
Structure name
co-crystal structure of human yy1 zinc finger domain bound to the adeno-associated virus p5 initiator element
Structure deposition date
1996-10-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
40
Minimum pKa ?
7
% buried
0
Peptide accession
P25490
Residue number A
385
Residue number B
390
Peptide name
Transcriptional repressor protein YY1

Ligandability

Cysteine 385 of Transcriptional repressor protein YY1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 390 of Transcriptional repressor protein YY1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcriptional repressor protein YY1 between cysteines 355 and 360.

Details

Redox score ?
88
PDB code
1ubd
Structure name
co-crystal structure of human yy1 zinc finger domain bound to the adeno-associated virus p5 initiator element
Structure deposition date
1996-10-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
40
Minimum pKa ?
7
% buried
0
Peptide accession
P25490
Residue number A
355
Residue number B
360
Peptide name
Transcriptional repressor protein YY1

Ligandability

Cysteine 355 of Transcriptional repressor protein YY1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 360 of Transcriptional repressor protein YY1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcriptional repressor protein YY1 between cysteines 298 and 303.

Details

Redox score ?
87
PDB code
1ubd
Structure name
co-crystal structure of human yy1 zinc finger domain bound to the adeno-associated virus p5 initiator element
Structure deposition date
1996-10-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
41
Minimum pKa ?
8
% buried
0
Peptide accession
P25490
Residue number A
298
Residue number B
303
Peptide name
Transcriptional repressor protein YY1

Ligandability

Cysteine 298 of Transcriptional repressor protein YY1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 303 of Transcriptional repressor protein YY1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: