Proteasome subunit alpha type-4

Intramolecular

A redox-regulated disulphide may form within Proteasome subunit alpha type-4 between cysteines 34 and 163. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

5lf4

Structure name

human 20s proteasome complex with delanzomib at 2

Structure deposition date

2016-06-30

Thiol separation (Å)

Half-sphere exposure sum ?

100

Minimum pK_a ?

% buried

Peptide accession

P25789

Residue number A

Residue number B

163

Peptide name

Proteasome subunit alpha type-4

Ligandability

Cysteine 34 of Proteasome subunit alpha type-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 163 of Proteasome subunit alpha type-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proteasome subunit alpha type-4 between cysteines 34 and 74. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

6epf

Structure name

ground state 26s proteasome (gs1)

Structure deposition date

2017-10-11

Thiol separation (Å)

Half-sphere exposure sum ?

101

Minimum pK_a ?

% buried

100

Peptide accession

P21670

Residue number A

Residue number B

Peptide name

Proteasome subunit alpha type-4

Ligandability

Cysteine 34 of Proteasome subunit alpha type-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 74 of Proteasome subunit alpha type-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proteasome subunit alpha type-4 between cysteines 74 and 107. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?