Rhombotin-2
Intramolecular
Cysteine 30 and cysteine 54
Cysteine 57 and cysteine 80
Cysteine 57 and cysteine 60
Cysteine 30 and cysteine 33
Cysteine 122 and cysteine 125
Cysteine 94 and cysteine 119
Cysteine 94 and cysteine 97
Cysteine 57 and cysteine 62
Cysteine 122 and cysteine 144
Cysteine 97 and cysteine 119
More...Cysteine 33 and cysteine 54
Cysteine 60 and cysteine 62
Cysteine 125 and cysteine 144
Cysteine 62 and cysteine 80
Cysteine 60 and cysteine 80
2xjy A 30 A 54
A redox-regulated disulphide may form within Rhombotin-2 between cysteines 30 and 54.
Details
Redox score ?
86
PDB code
2xjy
Structure name
crystal structure of the lmo2:ldb1-lid complex, p21 crystal form
Structure deposition date
2010-07-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
54
Minimum pKa ?
5
% buried
13
Peptide accession
P25791
Residue number A
30
Residue number B
54
Peptide name
Rhombotin-2
Ligandability
Cysteine 30 of Rhombotin-2
Cysteine 54 of Rhombotin-2
2xjz C 50 C 73
A redox-regulated disulphide may form within Rhombotin-2 between cysteines 57 and 80 (50 and 73 respectively in this structure).
Details
Redox score ?
85
PDB code
2xjz
Structure name
crystal structure of the lmo2:ldb1-lid complex, c2 crystal form
Structure deposition date
2010-07-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
63
Minimum pKa ?
5
% buried
58
Peptide accession
P25791
Residue number A
57
Residue number B
80
Peptide name
Rhombotin-2
Ligandability
Cysteine 57 of Rhombotin-2
Cysteine 80 of Rhombotin-2
2xjy A 57 A 60
A redox-regulated disulphide may form within Rhombotin-2 between cysteines 57 and 60.
Details
Redox score ?
84
PDB code
2xjy
Structure name
crystal structure of the lmo2:ldb1-lid complex, p21 crystal form
Structure deposition date
2010-07-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
43
Minimum pKa ?
7
% buried
19
Peptide accession
P25791
Residue number A
57
Residue number B
60
Peptide name
Rhombotin-2
Ligandability
Cysteine 57 of Rhombotin-2
Cysteine 60 of Rhombotin-2
2xjz D 23 D 26
A redox-regulated disulphide may form within Rhombotin-2 between cysteines 30 and 33 (23 and 26 respectively in this structure).
Details
Redox score ?
83
PDB code
2xjz
Structure name
crystal structure of the lmo2:ldb1-lid complex, c2 crystal form
Structure deposition date
2010-07-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
44
Minimum pKa ?
5
% buried
10
Peptide accession
P25791
Residue number A
30
Residue number B
33
Peptide name
Rhombotin-2
Ligandability
Cysteine 30 of Rhombotin-2
Cysteine 33 of Rhombotin-2
2xjy A 122 A 125
A redox-regulated disulphide may form within Rhombotin-2 between cysteines 122 and 125.
Details
Redox score ?
83
PDB code
2xjy
Structure name
crystal structure of the lmo2:ldb1-lid complex, p21 crystal form
Structure deposition date
2010-07-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
47
Minimum pKa ?
7
% buried
12
Peptide accession
P25791
Residue number A
122
Residue number B
125
Peptide name
Rhombotin-2
Ligandability
Cysteine 122 of Rhombotin-2
Cysteine 125 of Rhombotin-2
2xjz E 87 E 112
A redox-regulated disulphide may form within Rhombotin-2 between cysteines 94 and 119 (87 and 112 respectively in this structure).
Details
Redox score ?
81
PDB code
2xjz
Structure name
crystal structure of the lmo2:ldb1-lid complex, c2 crystal form
Structure deposition date
2010-07-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
6
% buried
37
Peptide accession
P25791
Residue number A
94
Residue number B
119
Peptide name
Rhombotin-2
Ligandability
Cysteine 94 of Rhombotin-2
Cysteine 119 of Rhombotin-2
4kfz B 94 B 97
A redox-regulated disulphide may form within Rhombotin-2 between cysteines 94 and 97.
Details
Redox score ?
81
PDB code
4kfz
Structure name
crystal structure of lmo2 and anti-lmo2 vh complex
Structure deposition date
2013-04-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
50
Minimum pKa ?
7
% buried
33
Peptide accession
P25791
Residue number A
94
Residue number B
97
Peptide name
Rhombotin-2
Ligandability
Cysteine 94 of Rhombotin-2
Cysteine 97 of Rhombotin-2
2xjz B 50 B 55
A redox-regulated disulphide may form within Rhombotin-2 between cysteines 57 and 62 (50 and 55 respectively in this structure).
Details
Redox score ?
80
PDB code
2xjz
Structure name
crystal structure of the lmo2:ldb1-lid complex, c2 crystal form
Structure deposition date
2010-07-06
Thiol separation (Å)
5
Half-sphere exposure sum ?
49
Minimum pKa ?
4
% buried
45
Peptide accession
P25791
Residue number A
57
Residue number B
62
Peptide name
Rhombotin-2
Ligandability
Cysteine 57 of Rhombotin-2
Cysteine 62 of Rhombotin-2
2xjz E 115 E 137
A redox-regulated disulphide may form within Rhombotin-2 between cysteines 122 and 144 (115 and 137 respectively in this structure).
Details
Redox score ?
80
PDB code
2xjz
Structure name
crystal structure of the lmo2:ldb1-lid complex, c2 crystal form
Structure deposition date
2010-07-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
63
Minimum pKa ?
7
% buried
22
Peptide accession
P25791
Residue number A
122
Residue number B
144
Peptide name
Rhombotin-2
Ligandability
Cysteine 122 of Rhombotin-2
Cysteine 144 of Rhombotin-2
2xjz B 90 B 112
A redox-regulated disulphide may form within Rhombotin-2 between cysteines 97 and 119 (90 and 112 respectively in this structure).
Details
Redox score ?
77
PDB code
2xjz
Structure name
crystal structure of the lmo2:ldb1-lid complex, c2 crystal form
Structure deposition date
2010-07-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
51
Minimum pKa ?
8
% buried
17
Peptide accession
P25791
Residue number A
97
Residue number B
119
Peptide name
Rhombotin-2
Ligandability
Cysteine 97 of Rhombotin-2
Cysteine 119 of Rhombotin-2
2xjz D 26 D 47
A redox-regulated disulphide may form within Rhombotin-2 between cysteines 33 and 54 (26 and 47 respectively in this structure).
Details
Redox score ?
77
PDB code
2xjz
Structure name
crystal structure of the lmo2:ldb1-lid complex, c2 crystal form
Structure deposition date
2010-07-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
48
Minimum pKa ?
8
% buried
6
Peptide accession
P25791
Residue number A
33
Residue number B
54
Peptide name
Rhombotin-2
Ligandability
Cysteine 33 of Rhombotin-2
Cysteine 54 of Rhombotin-2
4kfz B 60 B 62
A redox-regulated disulphide may form within Rhombotin-2 between cysteines 60 and 62.
Details
Redox score ?
76
PDB code
4kfz
Structure name
crystal structure of lmo2 and anti-lmo2 vh complex
Structure deposition date
2013-04-28
Thiol separation (Å)
3
Half-sphere exposure sum ?
84
Minimum pKa ?
7
% buried
94
Peptide accession
P25791
Residue number A
60
Residue number B
62
Peptide name
Rhombotin-2
Ligandability
Cysteine 60 of Rhombotin-2
Cysteine 62 of Rhombotin-2
2xjy A 125 A 144
A redox-regulated disulphide may form within Rhombotin-2 between cysteines 125 and 144.
Details
Redox score ?
75
PDB code
2xjy
Structure name
crystal structure of the lmo2:ldb1-lid complex, p21 crystal form
Structure deposition date
2010-07-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
51
Minimum pKa ?
9
% buried
8
Peptide accession
P25791
Residue number A
125
Residue number B
144
Peptide name
Rhombotin-2
Ligandability
Cysteine 125 of Rhombotin-2
Cysteine 144 of Rhombotin-2
2xjy A 62 A 80
A redox-regulated disulphide may form within Rhombotin-2 between cysteines 62 and 80.
Details
Redox score ?
69
PDB code
2xjy
Structure name
crystal structure of the lmo2:ldb1-lid complex, p21 crystal form
Structure deposition date
2010-07-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
10
% buried
28
Peptide accession
P25791
Residue number A
62
Residue number B
80
Peptide name
Rhombotin-2
Ligandability
Cysteine 62 of Rhombotin-2
Cysteine 80 of Rhombotin-2
4kfz A 60 A 80
A redox-regulated disulphide may form within Rhombotin-2 between cysteines 60 and 80. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
54
PDB code
4kfz
Structure name
crystal structure of lmo2 and anti-lmo2 vh complex
Structure deposition date
2013-04-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
77
Minimum pKa ?
17
% buried
90
Peptide accession
P25791
Residue number A
60
Residue number B
80
Peptide name
Rhombotin-2
Ligandability
Cysteine 60 of Rhombotin-2
Cysteine 80 of Rhombotin-2
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