ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Neuropeptide Y receptor type 1

Intramolecular
Cysteine 33 and cysteine 296
Cysteine 113 and cysteine 198
Cysteine 225 and cysteine 230
Cysteine 93 and cysteine 121
A redox-regulated disulphide may form within Neuropeptide Y receptor type 1 between cysteines 33 and 296.

Details

Redox score ?
87
PDB code
7x9a
Structure name
cryo-em structure of neuropeptide y y1 receptor in complex with npy and gi
Structure deposition date
2022-03-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
P25929
Residue number A
33
Residue number B
296
Peptide name
Neuropeptide Y receptor type 1

Ligandability

Cysteine 33 of Neuropeptide Y receptor type 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 296 of Neuropeptide Y receptor type 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Neuropeptide Y receptor type 1 between cysteines 113 and 198.

Details

Redox score ?
82
PDB code
7x9a
Structure name
cryo-em structure of neuropeptide y y1 receptor in complex with npy and gi
Structure deposition date
2022-03-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P25929
Residue number A
113
Residue number B
198
Peptide name
Neuropeptide Y receptor type 1

Ligandability

Cysteine 113 of Neuropeptide Y receptor type 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 198 of Neuropeptide Y receptor type 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Neuropeptide Y receptor type 1 between cysteines 225 and 230. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
7vgx
Structure name
neuropeptide y y1 receptor (npy1r) in complex with g protein and its endogeneous peptide-agonist neuropeptide y (npy)
Structure deposition date
2021-09-19
Thiol separation (Å)
10
Half-sphere exposure sum ?
49
Minimum pKa ?
9
% buried
15
Peptide accession
P25929
Residue number A
225
Residue number B
230
Peptide name
Neuropeptide Y receptor type 1

Ligandability

Cysteine 225 of Neuropeptide Y receptor type 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 230 of Neuropeptide Y receptor type 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Neuropeptide Y receptor type 1 between cysteines 93 and 121. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
7x9a
Structure name
cryo-em structure of neuropeptide y y1 receptor in complex with npy and gi
Structure deposition date
2022-03-15
Thiol separation (Å)
8
Half-sphere exposure sum ?
69
Minimum pKa ?
11
% buried
100
Peptide accession
P25929
Residue number A
93
Residue number B
121
Peptide name
Neuropeptide Y receptor type 1

Ligandability

Cysteine 93 of Neuropeptide Y receptor type 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 121 of Neuropeptide Y receptor type 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: