Tumor necrosis factor receptor superfamily member 5
Intramolecular
Cysteine 167 and cysteine 186
Cysteine 125 and cysteine 143
Cysteine 41 and cysteine 59
Cysteine 38 and cysteine 51
Cysteine 62 and cysteine 77
Cysteine 26 and cysteine 37
Cysteine 111 and cysteine 116
Cysteine 83 and cysteine 103
Cysteine 146 and cysteine 161
Cysteine 105 and cysteine 119
More...Cysteine 105 and cysteine 116
Cysteine 116 and cysteine 119
Cysteine 105 and cysteine 111
Cysteine 111 and cysteine 119
Cysteine 37 and cysteine 38
Cysteine 26 and cysteine 38
Cysteine 83 and cysteine 116
Cysteine 143 and cysteine 146
Cysteine 103 and cysteine 116
Cysteine 26 and cysteine 51
Cysteine 103 and cysteine 111
Cysteine 143 and cysteine 161
Cysteine 125 and cysteine 161
Cysteine 41 and cysteine 77
Cysteine 41 and cysteine 62
Cysteine 103 and cysteine 119
Cysteine 83 and cysteine 111
Cysteine 37 and cysteine 51
Cysteine 103 and cysteine 105
Cysteine 125 and cysteine 146
Cysteine 83 and cysteine 119
Cysteine 51 and cysteine 59
Cysteine 59 and cysteine 62
Cysteine 59 and cysteine 77
Cysteine 83 and cysteine 105
Cysteine 38 and cysteine 41
Cysteine 38 and cysteine 59
5dmj A 167 A 186
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 5 between cysteines 167 and 186.
Details
Redox score ?
90
PDB code
5dmj
Structure name
structure of the extracellular domain of the cd40 in complex with 3h56-5 dab
Structure deposition date
2015-09-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
40
Minimum pKa ?
nan
% buried
nan
Peptide accession
P25942
Residue number A
167
Residue number B
186
Peptide name
Tumor necrosis factor receptor superfamily member 5
Ligandability
Cysteine 167 of Tumor necrosis factor receptor superfamily member 5
Cysteine 186 of Tumor necrosis factor receptor superfamily member 5
7p3i C 125 C 143
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 5 between cysteines 125 and 143.
Details
Redox score ?
88
PDB code
7p3i
Structure name
crystal structure of human cd40/tnfrsf5 in complex with the anti-cd40 darpin protein
Structure deposition date
2021-07-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P25942
Residue number A
125
Residue number B
143
Peptide name
Tumor necrosis factor receptor superfamily member 5
Ligandability
Cysteine 125 of Tumor necrosis factor receptor superfamily member 5
Cysteine 143 of Tumor necrosis factor receptor superfamily member 5
3qd6 U 41 U 59
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 5 between cysteines 41 and 59.
Details
Redox score ?
87
PDB code
3qd6
Structure name
crystal structure of the cd40 and cd154 (cd40l) complex
Structure deposition date
2011-01-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P25942
Residue number A
41
Residue number B
59
Peptide name
Tumor necrosis factor receptor superfamily member 5
Ligandability
Cysteine 41 of Tumor necrosis factor receptor superfamily member 5
Cysteine 59 of Tumor necrosis factor receptor superfamily member 5
3qd6 T 38 T 51
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 5 between cysteines 38 and 51.
Details
Redox score ?
87
PDB code
3qd6
Structure name
crystal structure of the cd40 and cd154 (cd40l) complex
Structure deposition date
2011-01-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
P25942
Residue number A
38
Residue number B
51
Peptide name
Tumor necrosis factor receptor superfamily member 5
Ligandability
Cysteine 38 of Tumor necrosis factor receptor superfamily member 5
Cysteine 51 of Tumor necrosis factor receptor superfamily member 5
3qd6 U 62 U 77
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 5 between cysteines 62 and 77.
Details
Redox score ?
87
PDB code
3qd6
Structure name
crystal structure of the cd40 and cd154 (cd40l) complex
Structure deposition date
2011-01-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
P25942
Residue number A
62
Residue number B
77
Peptide name
Tumor necrosis factor receptor superfamily member 5
Ligandability
Cysteine 62 of Tumor necrosis factor receptor superfamily member 5
Cysteine 77 of Tumor necrosis factor receptor superfamily member 5
6fax R 26 R 37
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 5 between cysteines 26 and 37.
Details
Redox score ?
86
PDB code
6fax
Structure name
complex of human cd40 ectodomain with lob 7
Structure deposition date
2017-12-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
P25942
Residue number A
26
Residue number B
37
Peptide name
Tumor necrosis factor receptor superfamily member 5
Ligandability
Cysteine 26 of Tumor necrosis factor receptor superfamily member 5
Cysteine 37 of Tumor necrosis factor receptor superfamily member 5
3qd6 R 111 R 116
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 5 between cysteines 111 and 116.
Details
Redox score ?
86
PDB code
3qd6
Structure name
crystal structure of the cd40 and cd154 (cd40l) complex
Structure deposition date
2011-01-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
P25942
Residue number A
111
Residue number B
116
Peptide name
Tumor necrosis factor receptor superfamily member 5
Ligandability
Cysteine 111 of Tumor necrosis factor receptor superfamily member 5
Cysteine 116 of Tumor necrosis factor receptor superfamily member 5
3qd6 R 83 R 103
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 5 between cysteines 83 and 103.
Details
Redox score ?
86
PDB code
3qd6
Structure name
crystal structure of the cd40 and cd154 (cd40l) complex
Structure deposition date
2011-01-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
P25942
Residue number A
83
Residue number B
103
Peptide name
Tumor necrosis factor receptor superfamily member 5
Ligandability
Cysteine 83 of Tumor necrosis factor receptor superfamily member 5
Cysteine 103 of Tumor necrosis factor receptor superfamily member 5
7p3i C 146 C 161
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 5 between cysteines 146 and 161.
Details
Redox score ?
85
PDB code
7p3i
Structure name
crystal structure of human cd40/tnfrsf5 in complex with the anti-cd40 darpin protein
Structure deposition date
2021-07-07
Thiol separation (Å)
3
Half-sphere exposure sum ?
66
Minimum pKa ?
9
% buried
11
Peptide accession
P25942
Residue number A
146
Residue number B
161
Peptide name
Tumor necrosis factor receptor superfamily member 5
Ligandability
Cysteine 146 of Tumor necrosis factor receptor superfamily member 5
Cysteine 161 of Tumor necrosis factor receptor superfamily member 5
3qd6 R 105 R 119
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 5 between cysteines 105 and 119.
Details
Redox score ?
85
PDB code
3qd6
Structure name
crystal structure of the cd40 and cd154 (cd40l) complex
Structure deposition date
2011-01-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P25942
Residue number A
105
Residue number B
119
Peptide name
Tumor necrosis factor receptor superfamily member 5
Ligandability
Cysteine 105 of Tumor necrosis factor receptor superfamily member 5
Cysteine 119 of Tumor necrosis factor receptor superfamily member 5
3qd6 R 105 R 116
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 5 between cysteines 105 and 116.
Details
Redox score ?
81
PDB code
3qd6
Structure name
crystal structure of the cd40 and cd154 (cd40l) complex
Structure deposition date
2011-01-18
Thiol separation (Å)
3
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
P25942
Residue number A
105
Residue number B
116
Peptide name
Tumor necrosis factor receptor superfamily member 5
Ligandability
Cysteine 105 of Tumor necrosis factor receptor superfamily member 5
Cysteine 116 of Tumor necrosis factor receptor superfamily member 5
6pe9 G 116 G 119
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 5 between cysteines 116 and 119.
Details
Redox score ?
76
PDB code
6pe9
Structure name
crystal structure of cd40 complexed to fab516
Structure deposition date
2019-06-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
P25942
Residue number A
116
Residue number B
119
Peptide name
Tumor necrosis factor receptor superfamily member 5
Ligandability
Cysteine 116 of Tumor necrosis factor receptor superfamily member 5
Cysteine 119 of Tumor necrosis factor receptor superfamily member 5
5dmj D 105 D 111
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 5 between cysteines 105 and 111.
Details
Redox score ?
75
PDB code
5dmj
Structure name
structure of the extracellular domain of the cd40 in complex with 3h56-5 dab
Structure deposition date
2015-09-08
Thiol separation (Å)
4
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P25942
Residue number A
105
Residue number B
111
Peptide name
Tumor necrosis factor receptor superfamily member 5
Ligandability
Cysteine 105 of Tumor necrosis factor receptor superfamily member 5
Cysteine 111 of Tumor necrosis factor receptor superfamily member 5
5ihl D 111 D 119
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 5 between cysteines 111 and 119.
Details
Redox score ?
69
PDB code
5ihl
Structure name
structure of the extracellular domain of the cd40 in complex with 3h56-5 dab
Structure deposition date
2016-02-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
P25942
Residue number A
111
Residue number B
119
Peptide name
Tumor necrosis factor receptor superfamily member 5
Ligandability
Cysteine 111 of Tumor necrosis factor receptor superfamily member 5
Cysteine 119 of Tumor necrosis factor receptor superfamily member 5
6pe9 J 37 J 38
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 5 between cysteines 37 and 38. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
55
PDB code
6pe9
Structure name
crystal structure of cd40 complexed to fab516
Structure deposition date
2019-06-20
Thiol separation (Å)
7
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
P25942
Residue number A
37
Residue number B
38
Peptide name
Tumor necrosis factor receptor superfamily member 5
Ligandability
Cysteine 37 of Tumor necrosis factor receptor superfamily member 5
Cysteine 38 of Tumor necrosis factor receptor superfamily member 5
3qd6 U 26 U 38
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 5 between cysteines 26 and 38. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
51
PDB code
3qd6
Structure name
crystal structure of the cd40 and cd154 (cd40l) complex
Structure deposition date
2011-01-18
Thiol separation (Å)
8
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
P25942
Residue number A
26
Residue number B
38
Peptide name
Tumor necrosis factor receptor superfamily member 5
Ligandability
Cysteine 26 of Tumor necrosis factor receptor superfamily member 5
Cysteine 38 of Tumor necrosis factor receptor superfamily member 5
5dmj A 83 A 116
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 5 between cysteines 83 and 116. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
51
PDB code
5dmj
Structure name
structure of the extracellular domain of the cd40 in complex with 3h56-5 dab
Structure deposition date
2015-09-08
Thiol separation (Å)
8
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
P25942
Residue number A
83
Residue number B
116
Peptide name
Tumor necrosis factor receptor superfamily member 5
Ligandability
Cysteine 83 of Tumor necrosis factor receptor superfamily member 5
Cysteine 116 of Tumor necrosis factor receptor superfamily member 5
5ihl F 143 F 146
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 5 between cysteines 143 and 146. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
51
PDB code
5ihl
Structure name
structure of the extracellular domain of the cd40 in complex with 3h56-5 dab
Structure deposition date
2016-02-29
Thiol separation (Å)
9
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
P25942
Residue number A
143
Residue number B
146
Peptide name
Tumor necrosis factor receptor superfamily member 5
Ligandability
Cysteine 143 of Tumor necrosis factor receptor superfamily member 5
Cysteine 146 of Tumor necrosis factor receptor superfamily member 5
7p3i A 103 A 116
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 5 between cysteines 103 and 116. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
7p3i
Structure name
crystal structure of human cd40/tnfrsf5 in complex with the anti-cd40 darpin protein
Structure deposition date
2021-07-07
Thiol separation (Å)
8
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
P25942
Residue number A
103
Residue number B
116
Peptide name
Tumor necrosis factor receptor superfamily member 5
Ligandability
Cysteine 103 of Tumor necrosis factor receptor superfamily member 5
Cysteine 116 of Tumor necrosis factor receptor superfamily member 5
3qd6 U 26 U 51
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 5 between cysteines 26 and 51. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
3qd6
Structure name
crystal structure of the cd40 and cd154 (cd40l) complex
Structure deposition date
2011-01-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
42
Minimum pKa ?
nan
% buried
nan
Peptide accession
P25942
Residue number A
26
Residue number B
51
Peptide name
Tumor necrosis factor receptor superfamily member 5
Ligandability
Cysteine 26 of Tumor necrosis factor receptor superfamily member 5
Cysteine 51 of Tumor necrosis factor receptor superfamily member 5
6fax R 103 R 111
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 5 between cysteines 103 and 111. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
6fax
Structure name
complex of human cd40 ectodomain with lob 7
Structure deposition date
2017-12-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
P25942
Residue number A
103
Residue number B
111
Peptide name
Tumor necrosis factor receptor superfamily member 5
Ligandability
Cysteine 103 of Tumor necrosis factor receptor superfamily member 5
Cysteine 111 of Tumor necrosis factor receptor superfamily member 5
6pe8 T 143 T 161
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 5 between cysteines 143 and 161. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
6pe8
Structure name
crystal structure of cd40/abbv-323 fab complex
Structure deposition date
2019-06-20
Thiol separation (Å)
9
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P25942
Residue number A
143
Residue number B
161
Peptide name
Tumor necrosis factor receptor superfamily member 5
Ligandability
Cysteine 143 of Tumor necrosis factor receptor superfamily member 5
Cysteine 161 of Tumor necrosis factor receptor superfamily member 5
5ihl A 125 A 161
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 5 between cysteines 125 and 161. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
5ihl
Structure name
structure of the extracellular domain of the cd40 in complex with 3h56-5 dab
Structure deposition date
2016-02-29
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P25942
Residue number A
125
Residue number B
161
Peptide name
Tumor necrosis factor receptor superfamily member 5
Ligandability
Cysteine 125 of Tumor necrosis factor receptor superfamily member 5
Cysteine 161 of Tumor necrosis factor receptor superfamily member 5
6fax R 41 R 77
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 5 between cysteines 41 and 77. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
6fax
Structure name
complex of human cd40 ectodomain with lob 7
Structure deposition date
2017-12-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P25942
Residue number A
41
Residue number B
77
Peptide name
Tumor necrosis factor receptor superfamily member 5
Ligandability
Cysteine 41 of Tumor necrosis factor receptor superfamily member 5
Cysteine 77 of Tumor necrosis factor receptor superfamily member 5
5dmi A 41 A 62
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 5 between cysteines 41 and 62. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
5dmi
Structure name
structure of the extracellular domain of the cd40 in complex with chi220 fab
Structure deposition date
2015-09-08
Thiol separation (Å)
9
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P25942
Residue number A
41
Residue number B
62
Peptide name
Tumor necrosis factor receptor superfamily member 5
Ligandability
Cysteine 41 of Tumor necrosis factor receptor superfamily member 5
Cysteine 62 of Tumor necrosis factor receptor superfamily member 5
3qd6 R 103 R 119
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 5 between cysteines 103 and 119. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
3qd6
Structure name
crystal structure of the cd40 and cd154 (cd40l) complex
Structure deposition date
2011-01-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P25942
Residue number A
103
Residue number B
119
Peptide name
Tumor necrosis factor receptor superfamily member 5
Ligandability
Cysteine 103 of Tumor necrosis factor receptor superfamily member 5
Cysteine 119 of Tumor necrosis factor receptor superfamily member 5
5ihl H 83 H 111
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 5 between cysteines 83 and 111. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
5ihl
Structure name
structure of the extracellular domain of the cd40 in complex with 3h56-5 dab
Structure deposition date
2016-02-29
Thiol separation (Å)
9
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
P25942
Residue number A
83
Residue number B
111
Peptide name
Tumor necrosis factor receptor superfamily member 5
Ligandability
Cysteine 83 of Tumor necrosis factor receptor superfamily member 5
Cysteine 111 of Tumor necrosis factor receptor superfamily member 5
6pe8 T 37 T 51
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 5 between cysteines 37 and 51. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
6pe8
Structure name
crystal structure of cd40/abbv-323 fab complex
Structure deposition date
2019-06-20
Thiol separation (Å)
9
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide accession
P25942
Residue number A
37
Residue number B
51
Peptide name
Tumor necrosis factor receptor superfamily member 5
Ligandability
Cysteine 37 of Tumor necrosis factor receptor superfamily member 5
Cysteine 51 of Tumor necrosis factor receptor superfamily member 5
5ihl H 103 H 105
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 5 between cysteines 103 and 105. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
5ihl
Structure name
structure of the extracellular domain of the cd40 in complex with 3h56-5 dab
Structure deposition date
2016-02-29
Thiol separation (Å)
9
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P25942
Residue number A
103
Residue number B
105
Peptide name
Tumor necrosis factor receptor superfamily member 5
Ligandability
Cysteine 103 of Tumor necrosis factor receptor superfamily member 5
Cysteine 105 of Tumor necrosis factor receptor superfamily member 5
7p3i C 125 C 146
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 5 between cysteines 125 and 146. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
7p3i
Structure name
crystal structure of human cd40/tnfrsf5 in complex with the anti-cd40 darpin protein
Structure deposition date
2021-07-07
Thiol separation (Å)
9
Half-sphere exposure sum ?
63
Minimum pKa ?
11
% buried
nan
Peptide accession
P25942
Residue number A
125
Residue number B
146
Peptide name
Tumor necrosis factor receptor superfamily member 5
Ligandability
Cysteine 125 of Tumor necrosis factor receptor superfamily member 5
Cysteine 146 of Tumor necrosis factor receptor superfamily member 5
7p3i A 83 A 119
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 5 between cysteines 83 and 119. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
7p3i
Structure name
crystal structure of human cd40/tnfrsf5 in complex with the anti-cd40 darpin protein
Structure deposition date
2021-07-07
Thiol separation (Å)
10
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P25942
Residue number A
83
Residue number B
119
Peptide name
Tumor necrosis factor receptor superfamily member 5
Ligandability
Cysteine 83 of Tumor necrosis factor receptor superfamily member 5
Cysteine 119 of Tumor necrosis factor receptor superfamily member 5
3qd6 S 51 S 59
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 5 between cysteines 51 and 59. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
3qd6
Structure name
crystal structure of the cd40 and cd154 (cd40l) complex
Structure deposition date
2011-01-18
Thiol separation (Å)
10
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
P25942
Residue number A
51
Residue number B
59
Peptide name
Tumor necrosis factor receptor superfamily member 5
Ligandability
Cysteine 51 of Tumor necrosis factor receptor superfamily member 5
Cysteine 59 of Tumor necrosis factor receptor superfamily member 5
3qd6 R 59 R 62
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 5 between cysteines 59 and 62. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
3qd6
Structure name
crystal structure of the cd40 and cd154 (cd40l) complex
Structure deposition date
2011-01-18
Thiol separation (Å)
10
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P25942
Residue number A
59
Residue number B
62
Peptide name
Tumor necrosis factor receptor superfamily member 5
Ligandability
Cysteine 59 of Tumor necrosis factor receptor superfamily member 5
Cysteine 62 of Tumor necrosis factor receptor superfamily member 5
6fax R 59 R 77
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 5 between cysteines 59 and 77. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
6fax
Structure name
complex of human cd40 ectodomain with lob 7
Structure deposition date
2017-12-18
Thiol separation (Å)
10
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
P25942
Residue number A
59
Residue number B
77
Peptide name
Tumor necrosis factor receptor superfamily member 5
Ligandability
Cysteine 59 of Tumor necrosis factor receptor superfamily member 5
Cysteine 77 of Tumor necrosis factor receptor superfamily member 5
5dmi A 83 A 105
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 5 between cysteines 83 and 105. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
5dmi
Structure name
structure of the extracellular domain of the cd40 in complex with chi220 fab
Structure deposition date
2015-09-08
Thiol separation (Å)
10
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P25942
Residue number A
83
Residue number B
105
Peptide name
Tumor necrosis factor receptor superfamily member 5
Ligandability
Cysteine 83 of Tumor necrosis factor receptor superfamily member 5
Cysteine 105 of Tumor necrosis factor receptor superfamily member 5
3qd6 T 38 T 41
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 5 between cysteines 38 and 41. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
3qd6
Structure name
crystal structure of the cd40 and cd154 (cd40l) complex
Structure deposition date
2011-01-18
Thiol separation (Å)
10
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P25942
Residue number A
38
Residue number B
41
Peptide name
Tumor necrosis factor receptor superfamily member 5
Ligandability
Cysteine 38 of Tumor necrosis factor receptor superfamily member 5
Cysteine 41 of Tumor necrosis factor receptor superfamily member 5
5ihl A 38 A 59
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 5 between cysteines 38 and 59. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
5ihl
Structure name
structure of the extracellular domain of the cd40 in complex with 3h56-5 dab
Structure deposition date
2016-02-29
Thiol separation (Å)
10
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P25942
Residue number A
38
Residue number B
59
Peptide name
Tumor necrosis factor receptor superfamily member 5
Ligandability
Cysteine 38 of Tumor necrosis factor receptor superfamily member 5
Cysteine 59 of Tumor necrosis factor receptor superfamily member 5
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