ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Pentraxin-related protein PTX3

Intermolecular
Cysteine 318 and cysteine 317
Cysteine 317 and cysteine 317
Cysteine 318 and cysteine 318
A redox-regulated disulphide may form between two units of Pentraxin-related protein PTX3 at cysteines 318 and 317.

Details

Redox score ?
85
PDB code
7zl1
Structure name
ptx3 pentraxin domain
Structure deposition date
2022-04-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide A name
Pentraxin-related protein PTX3
Peptide B name
Pentraxin-related protein PTX3
Peptide A accession
P26022
Peptide B accession
P26022
Peptide A residue number
318
Peptide B residue number
317

Ligandability

Cysteine 318 of Pentraxin-related protein PTX3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 317 of Pentraxin-related protein PTX3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Pentraxin-related protein PTX3 at cysteines 317 and 317.

Details

Redox score ?
65
PDB code
7zl1
Structure name
ptx3 pentraxin domain
Structure deposition date
2022-04-13
Thiol separation (Å)
5
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide A name
Pentraxin-related protein PTX3
Peptide B name
Pentraxin-related protein PTX3
Peptide A accession
P26022
Peptide B accession
P26022
Peptide A residue number
317
Peptide B residue number
317

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Pentraxin-related protein PTX3 at cysteines 318 and 318.

Details

Redox score ?
62
PDB code
7zl1
Structure name
ptx3 pentraxin domain
Structure deposition date
2022-04-13
Thiol separation (Å)
5
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide A name
Pentraxin-related protein PTX3
Peptide B name
Pentraxin-related protein PTX3
Peptide A accession
P26022
Peptide B accession
P26022
Peptide A residue number
318
Peptide B residue number
318

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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