ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Intramolecular
Cysteine 115 and cysteine 145
Cysteine 239 and cysteine 305
A redox-regulated disulphide may form within Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase between cysteines 115 and 145.

Details

Redox score ?
80
PDB code
1fo9
Structure name
crystal structure of n-acetylglucosaminyltransferase i
Structure deposition date
2000-08-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P27115
Residue number A
115
Residue number B
145
Peptide name
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Ligandability

Cysteine 115 of Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 145 of Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase between cysteines 239 and 305.

Details

Redox score ?
77
PDB code
2am5
Structure name
crystal structure of n-acetylglucosaminyltransferase i in complex with udp
Structure deposition date
2005-08-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
P27115
Residue number A
239
Residue number B
305
Peptide name
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Ligandability

Cysteine 239 of Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 305 of Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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