ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

mRNA decay activator protein ZFP36

Intramolecular
Cysteine 110 and cysteine 116
Cysteine 101 and cysteine 110
Cysteine 101 and cysteine 116
A redox-regulated disulphide may form within mRNA decay activator protein ZFP36 between cysteines 110 and 116 (24 and 30 respectively in this structure).

Details

Redox score ?
83
PDB code
1m9o
Structure name
nmr structure of the first zinc binding domain of nup475/ttp/tis11
Structure deposition date
2002-07-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
47
Minimum pKa ?
8
% buried
0
Peptide accession
P22893
Residue number A
110
Residue number B
116
Peptide name
mRNA decay activator protein ZFP36

Ligandability

Cysteine 110 of mRNA decay activator protein ZFP36

Cysteine 116 of mRNA decay activator protein ZFP36

A redox-regulated disulphide may form within mRNA decay activator protein ZFP36 between cysteines 101 and 110 (15 and 24 respectively in this structure).

Details

Redox score ?
82
PDB code
1m9o
Structure name
nmr structure of the first zinc binding domain of nup475/ttp/tis11
Structure deposition date
2002-07-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
52
Minimum pKa ?
8
% buried
0
Peptide accession
P22893
Residue number A
101
Residue number B
110
Peptide name
mRNA decay activator protein ZFP36

Ligandability

Cysteine 101 of mRNA decay activator protein ZFP36

Cysteine 110 of mRNA decay activator protein ZFP36

A redox-regulated disulphide may form within mRNA decay activator protein ZFP36 between cysteines 101 and 116 (15 and 30 respectively in this structure).

Details

Redox score ?
81
PDB code
1m9o
Structure name
nmr structure of the first zinc binding domain of nup475/ttp/tis11
Structure deposition date
2002-07-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
51
Minimum pKa ?
8
% buried
0
Peptide accession
P22893
Residue number A
101
Residue number B
116
Peptide name
mRNA decay activator protein ZFP36

Ligandability

Cysteine 101 of mRNA decay activator protein ZFP36

Cysteine 116 of mRNA decay activator protein ZFP36

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