ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Cardiac phospholamban

Intermolecular
Cysteine 41 and cysteine 36
Cysteine 41 and cysteine 41
Cysteine 36 and cysteine 36
Intramolecular
Cysteine 41 and cysteine 46
Cysteine 36 and cysteine 41
A redox-regulated disulphide may form between two units of Cardiac phospholamban at cysteines 41 and 36.

Details

Redox score ?
80
PDB code
2m3b
Structure name
serine 16 phosphorylated phospholamban pentamer, hybrid solution and solid-state nmr structural ensemble
Structure deposition date
2013-01-15
Thiol separation (Å)
3
Half-sphere exposure sum ?
60
Minimum pKa ?
8
% buried
52
Peptide A name
Cardiac phospholamban
Peptide B name
Cardiac phospholamban
Peptide A accession
P61015
Peptide B accession
P61015
Peptide A residue number
41
Peptide B residue number
36

Ligandability

Cysteine 41 of Cardiac phospholamban

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 36 of Cardiac phospholamban

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Cardiac phospholamban at cysteines 41 and 41. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
2m3b
Structure name
serine 16 phosphorylated phospholamban pentamer, hybrid solution and solid-state nmr structural ensemble
Structure deposition date
2013-01-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
59
Minimum pKa ?
8
% buried
50
Peptide A name
Cardiac phospholamban
Peptide B name
Cardiac phospholamban
Peptide A accession
P61015
Peptide B accession
P61015
Peptide A residue number
41
Peptide B residue number
41

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Cardiac phospholamban at cysteines 36 and 36. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
2m3b
Structure name
serine 16 phosphorylated phospholamban pentamer, hybrid solution and solid-state nmr structural ensemble
Structure deposition date
2013-01-15
Thiol separation (Å)
10
Half-sphere exposure sum ?
60
Minimum pKa ?
12
% buried
53
Peptide A name
Cardiac phospholamban
Peptide B name
Cardiac phospholamban
Peptide A accession
P61015
Peptide B accession
P61015
Peptide A residue number
36
Peptide B residue number
36

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cardiac phospholamban between cysteines 41 and 46. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
2hyn
Structure name
complete ensemble of nmr structures of unphosphorylated human phospholamban pentamer
Structure deposition date
2006-08-07
Thiol separation (Å)
9
Half-sphere exposure sum ?
58
Minimum pKa ?
9
% buried
20
Peptide accession
P26678
Residue number A
41
Residue number B
46
Peptide name
Cardiac phospholamban

Ligandability

Cysteine 41 of Cardiac phospholamban

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 46 of Cardiac phospholamban

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cardiac phospholamban between cysteines 36 and 41. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
26
PDB code
2hyn
Structure name
complete ensemble of nmr structures of unphosphorylated human phospholamban pentamer
Structure deposition date
2006-08-07
Thiol separation (Å)
8
Half-sphere exposure sum ?
64
Minimum pKa ?
20
% buried
44
Peptide accession
P26678
Residue number A
36
Residue number B
41
Peptide name
Cardiac phospholamban

Ligandability

Cysteine 36 of Cardiac phospholamban

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 41 of Cardiac phospholamban

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: