ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

NKG2-A/NKG2-B type II integral membrane protein

Intermolecular
Cysteine 59 of Natural killer cells antigen CD94 and cysteine 116
Cysteine 58 of Natural killer cells antigen CD94 and cysteine 116
Cysteine 61 of Natural killer cells antigen CD94 and cysteine 116
Cysteine 70 of Natural killer cells antigen CD94 and cysteine 116
Cysteine 59 of Natural killer cells antigen CD94 and cysteine 119
Cysteine 59 of Natural killer cells antigen CD94 and cysteine 130
Cysteine 72 of Natural killer cells antigen CD94 and cysteine 116
Intramolecular
Cysteine 119 and cysteine 130
Cysteine 208 and cysteine 221
Cysteine 147 and cysteine 229
More...
Cysteine 116 and cysteine 119
Cysteine 116 and cysteine 130
A redox-regulated disulphide may form between cysteine 59 of Natural killer cells antigen CD94 and cysteine 116 of NKG2-A/NKG2-B type II integral membrane protein.

Details

Redox score ?
71
PDB code
3cii
Structure name
structure of nkg2a/cd94 bound to hla-e
Structure deposition date
2008-03-11
Thiol separation (Å)
6
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
nan
Peptide A name
Natural killer cells antigen CD94
Peptide B name
NKG2-A/NKG2-B type II integral membrane protein
Peptide A accession
Q13241
Peptide B accession
P26715
Peptide A residue number
59
Peptide B residue number
116

Ligandability

Cysteine 59 of Natural killer cells antigen CD94

Cysteine 116 of NKG2-A/NKG2-B type II integral membrane protein

A redox-regulated disulphide may form between cysteine 58 of Natural killer cells antigen CD94 and cysteine 116 of NKG2-A/NKG2-B type II integral membrane protein.

Details

Redox score ?
65
PDB code
3cdg
Structure name
human cd94/nkg2a in complex with hla-e
Structure deposition date
2008-02-26
Thiol separation (Å)
6
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide A name
Natural killer cells antigen CD94
Peptide B name
NKG2-A/NKG2-B type II integral membrane protein
Peptide A accession
Q13241
Peptide B accession
P26715
Peptide A residue number
58
Peptide B residue number
116

Ligandability

Cysteine 58 of Natural killer cells antigen CD94

Cysteine 116 of NKG2-A/NKG2-B type II integral membrane protein

A redox-regulated disulphide may form between cysteine 61 of Natural killer cells antigen CD94 and cysteine 116 of NKG2-A/NKG2-B type II integral membrane protein. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
3bdw
Structure name
human cd94/nkg2a
Structure deposition date
2007-11-15
Thiol separation (Å)
7
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide A name
Natural killer cells antigen CD94
Peptide B name
NKG2-A/NKG2-B type II integral membrane protein
Peptide A accession
Q13241
Peptide B accession
P26715
Peptide A residue number
61
Peptide B residue number
116

Ligandability

Cysteine 61 of Natural killer cells antigen CD94

Cysteine 116 of NKG2-A/NKG2-B type II integral membrane protein

A redox-regulated disulphide may form between cysteine 70 of Natural killer cells antigen CD94 and cysteine 116 of NKG2-A/NKG2-B type II integral membrane protein. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
3cii
Structure name
structure of nkg2a/cd94 bound to hla-e
Structure deposition date
2008-03-11
Thiol separation (Å)
7
Half-sphere exposure sum ?
58
Minimum pKa ?
9
% buried
nan
Peptide A name
Natural killer cells antigen CD94
Peptide B name
NKG2-A/NKG2-B type II integral membrane protein
Peptide A accession
Q13241
Peptide B accession
P26715
Peptide A residue number
70
Peptide B residue number
116

Ligandability

Cysteine 70 of Natural killer cells antigen CD94

Cysteine 116 of NKG2-A/NKG2-B type II integral membrane protein

A redox-regulated disulphide may form between cysteine 59 of Natural killer cells antigen CD94 and cysteine 119 of NKG2-A/NKG2-B type II integral membrane protein. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
3bdw
Structure name
human cd94/nkg2a
Structure deposition date
2007-11-15
Thiol separation (Å)
7
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide A name
Natural killer cells antigen CD94
Peptide B name
NKG2-A/NKG2-B type II integral membrane protein
Peptide A accession
Q13241
Peptide B accession
P26715
Peptide A residue number
59
Peptide B residue number
119

Ligandability

Cysteine 59 of Natural killer cells antigen CD94

Cysteine 119 of NKG2-A/NKG2-B type II integral membrane protein

A redox-regulated disulphide may form between cysteine 59 of Natural killer cells antigen CD94 and cysteine 130 of NKG2-A/NKG2-B type II integral membrane protein. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
3bdw
Structure name
human cd94/nkg2a
Structure deposition date
2007-11-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide A name
Natural killer cells antigen CD94
Peptide B name
NKG2-A/NKG2-B type II integral membrane protein
Peptide A accession
Q13241
Peptide B accession
P26715
Peptide A residue number
59
Peptide B residue number
130

Ligandability

Cysteine 59 of Natural killer cells antigen CD94

Cysteine 130 of NKG2-A/NKG2-B type II integral membrane protein

A redox-regulated disulphide may form between cysteine 72 of Natural killer cells antigen CD94 and cysteine 116 of NKG2-A/NKG2-B type II integral membrane protein. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
3cii
Structure name
structure of nkg2a/cd94 bound to hla-e
Structure deposition date
2008-03-11
Thiol separation (Å)
10
Half-sphere exposure sum ?
64
Minimum pKa ?
9
% buried
nan
Peptide A name
Natural killer cells antigen CD94
Peptide B name
NKG2-A/NKG2-B type II integral membrane protein
Peptide A accession
Q13241
Peptide B accession
P26715
Peptide A residue number
72
Peptide B residue number
116

Ligandability

Cysteine 72 of Natural killer cells antigen CD94

Cysteine 116 of NKG2-A/NKG2-B type II integral membrane protein

A redox-regulated disulphide may form within NKG2-A/NKG2-B type II integral membrane protein between cysteines 119 and 130.

Details

Redox score ?
85
PDB code
3cdg
Structure name
human cd94/nkg2a in complex with hla-e
Structure deposition date
2008-02-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P26715
Residue number A
119
Residue number B
130
Peptide name
NKG2-A/NKG2-B type II integral membrane protein

Ligandability

Cysteine 119 of NKG2-A/NKG2-B type II integral membrane protein

Cysteine 130 of NKG2-A/NKG2-B type II integral membrane protein

A redox-regulated disulphide may form within NKG2-A/NKG2-B type II integral membrane protein between cysteines 208 and 221.

Details

Redox score ?
84
PDB code
3bdw
Structure name
human cd94/nkg2a
Structure deposition date
2007-11-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P26715
Residue number A
208
Residue number B
221
Peptide name
NKG2-A/NKG2-B type II integral membrane protein

Ligandability

Cysteine 208 of NKG2-A/NKG2-B type II integral membrane protein

Cysteine 221 of NKG2-A/NKG2-B type II integral membrane protein

A redox-regulated disulphide may form within NKG2-A/NKG2-B type II integral membrane protein between cysteines 147 and 229.

Details

Redox score ?
81
PDB code
3cii
Structure name
structure of nkg2a/cd94 bound to hla-e
Structure deposition date
2008-03-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P26715
Residue number A
147
Residue number B
229
Peptide name
NKG2-A/NKG2-B type II integral membrane protein

Ligandability

Cysteine 147 of NKG2-A/NKG2-B type II integral membrane protein

Cysteine 229 of NKG2-A/NKG2-B type II integral membrane protein

A redox-regulated disulphide may form within NKG2-A/NKG2-B type II integral membrane protein between cysteines 116 and 119.

Details

Redox score ?
69
PDB code
3bdw
Structure name
human cd94/nkg2a
Structure deposition date
2007-11-15
Thiol separation (Å)
5
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
P26715
Residue number A
116
Residue number B
119
Peptide name
NKG2-A/NKG2-B type II integral membrane protein

Ligandability

Cysteine 116 of NKG2-A/NKG2-B type II integral membrane protein

Cysteine 119 of NKG2-A/NKG2-B type II integral membrane protein

A redox-regulated disulphide may form within NKG2-A/NKG2-B type II integral membrane protein between cysteines 116 and 130. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
3bdw
Structure name
human cd94/nkg2a
Structure deposition date
2007-11-15
Thiol separation (Å)
7
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P26715
Residue number A
116
Residue number B
130
Peptide name
NKG2-A/NKG2-B type II integral membrane protein

Ligandability

Cysteine 116 of NKG2-A/NKG2-B type II integral membrane protein

Cysteine 130 of NKG2-A/NKG2-B type II integral membrane protein

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