NKG2-D type II integral membrane protein
Intermolecular
Cysteine 96 and cysteine 96
Cysteine 105 and cysteine 96
Cysteine 105 and cysteine 105
Intramolecular
Cysteine 99 and cysteine 110
Cysteine 127 and cysteine 211
Cysteine 189 and cysteine 203
Cysteine 99 and cysteine 105
Cysteine 105 and cysteine 110
Cysteine 96 and cysteine 99
Cysteine 96 and cysteine 110
4pdc C 96 D 96
A redox-regulated disulphide may form between two units of NKG2-D type II integral membrane protein at cysteines 96 and 96. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
58
PDB code
4pdc
Structure name
crystal structure of cowpox virus cpxv018 (omcp) bound to human nkg2d
Structure deposition date
2014-04-17
Thiol separation (Å)
6
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide A name
NKG2-D type II integral membrane protein
Peptide B name
NKG2-D type II integral membrane protein
Peptide A accession
P26718
Peptide B accession
P26718
Peptide A residue number
96
Peptide B residue number
96
Ligandability
7fi5 A 105 B 96
A redox-regulated disulphide may form between two units of NKG2-D type II integral membrane protein at cysteines 105 and 96. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
58
PDB code
7fi5
Structure name
crystal structure of human mica mutants in complex with natural killer cell receptor nkg2d
Structure deposition date
2021-07-30
Thiol separation (Å)
6
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide A name
NKG2-D type II integral membrane protein
Peptide B name
NKG2-D type II integral membrane protein
Peptide A accession
P26718
Peptide B accession
P26718
Peptide A residue number
105
Peptide B residue number
96
Ligandability
Cysteine 105 of NKG2-D type II integral membrane protein
Cysteine 96 of NKG2-D type II integral membrane protein
4pdc C 105 D 105
A redox-regulated disulphide may form between two units of NKG2-D type II integral membrane protein at cysteines 105 and 105. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
56
PDB code
4pdc
Structure name
crystal structure of cowpox virus cpxv018 (omcp) bound to human nkg2d
Structure deposition date
2014-04-17
Thiol separation (Å)
6
Half-sphere exposure sum ?
86
Minimum pKa ?
nan
% buried
nan
Peptide A name
NKG2-D type II integral membrane protein
Peptide B name
NKG2-D type II integral membrane protein
Peptide A accession
P26718
Peptide B accession
P26718
Peptide A residue number
105
Peptide B residue number
105
Ligandability
7fi6 B 99 B 110
A redox-regulated disulphide may form within NKG2-D type II integral membrane protein between cysteines 99 and 110.
Details
Redox score ?
85
PDB code
7fi6
Structure name
crystal structure of human mica mutants in complex with natural killer cell receptor nkg2d
Structure deposition date
2021-07-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P26718
Residue number A
99
Residue number B
110
Peptide name
NKG2-D type II integral membrane protein
Ligandability
Cysteine 99 of NKG2-D type II integral membrane protein
Cysteine 110 of NKG2-D type II integral membrane protein
7fi7 A 127 A 211
A redox-regulated disulphide may form within NKG2-D type II integral membrane protein between cysteines 127 and 211.
Details
Redox score ?
82
PDB code
7fi7
Structure name
crystal structure of human mica mutants in complex with natural killer cell receptor nkg2d
Structure deposition date
2021-07-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P26718
Residue number A
127
Residue number B
211
Peptide name
NKG2-D type II integral membrane protein
Ligandability
Cysteine 127 of NKG2-D type II integral membrane protein
Cysteine 211 of NKG2-D type II integral membrane protein
4pdc C 189 C 203
A redox-regulated disulphide may form within NKG2-D type II integral membrane protein between cysteines 189 and 203.
Details
Redox score ?
81
PDB code
4pdc
Structure name
crystal structure of cowpox virus cpxv018 (omcp) bound to human nkg2d
Structure deposition date
2014-04-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide accession
P26718
Residue number A
189
Residue number B
203
Peptide name
NKG2-D type II integral membrane protein
Ligandability
Cysteine 189 of NKG2-D type II integral membrane protein
Cysteine 203 of NKG2-D type II integral membrane protein
1kcg A 99 A 105
A redox-regulated disulphide may form within NKG2-D type II integral membrane protein between cysteines 99 and 105.
Details
Redox score ?
75
PDB code
1kcg
Structure name
nkg2d in complex with ulbp3
Structure deposition date
2001-11-08
Thiol separation (Å)
3
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
P26718
Residue number A
99
Residue number B
105
Peptide name
NKG2-D type II integral membrane protein
Ligandability
Cysteine 99 of NKG2-D type II integral membrane protein
Cysteine 105 of NKG2-D type II integral membrane protein
4s0u A 105 A 110
A redox-regulated disulphide may form within NKG2-D type II integral membrane protein between cysteines 105 and 110.
Details
Redox score ?
65
PDB code
4s0u
Structure name
crystal structure of nkg2d in complex with ulbp6
Structure deposition date
2015-01-06
Thiol separation (Å)
5
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide accession
P26718
Residue number A
105
Residue number B
110
Peptide name
NKG2-D type II integral membrane protein
Ligandability
Cysteine 105 of NKG2-D type II integral membrane protein
Cysteine 110 of NKG2-D type II integral membrane protein
7fi9 A 96 A 99
A redox-regulated disulphide may form within NKG2-D type II integral membrane protein between cysteines 96 and 99.
Details
Redox score ?
64
PDB code
7fi9
Structure name
crystal structure of human mica mutants in complex with natural killer cell receptor nkg2d
Structure deposition date
2021-07-30
Thiol separation (Å)
6
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P26718
Residue number A
96
Residue number B
99
Peptide name
NKG2-D type II integral membrane protein
Ligandability
Cysteine 96 of NKG2-D type II integral membrane protein
Cysteine 99 of NKG2-D type II integral membrane protein
7fi9 A 96 A 110
A redox-regulated disulphide may form within NKG2-D type II integral membrane protein between cysteines 96 and 110. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
7fi9
Structure name
crystal structure of human mica mutants in complex with natural killer cell receptor nkg2d
Structure deposition date
2021-07-30
Thiol separation (Å)
7
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
P26718
Residue number A
96
Residue number B
110
Peptide name
NKG2-D type II integral membrane protein
Ligandability
Cysteine 96 of NKG2-D type II integral membrane protein
Cysteine 110 of NKG2-D type II integral membrane protein
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