ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Peptidyl-prolyl cis-trans isomerase FKBP2

Intermolecular
Cysteine 97 and cysteine 97
Intramolecular
Cysteine 42 and cysteine 97
A redox-regulated disulphide may form between two units of Peptidyl-prolyl cis-trans isomerase FKBP2 at cysteines 97 and 97. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
2pbc
Structure name
fk506-binding protein 2
Structure deposition date
2007-03-28
Thiol separation (Å)
8
Half-sphere exposure sum ?
68
Minimum pKa ?
10
% buried
43
Peptide A name
Peptidyl-prolyl cis-trans isomerase FKBP2
Peptide B name
Peptidyl-prolyl cis-trans isomerase FKBP2
Peptide A accession
P26885
Peptide B accession
P26885
Peptide A residue number
97
Peptide B residue number
97

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peptidyl-prolyl cis-trans isomerase FKBP2 between cysteines 42 and 97.

Details

Redox score ?
87
PDB code
4nnr
Structure name
fkbp13-fk506 complex
Structure deposition date
2013-11-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
38
Minimum pKa ?
nan
% buried
nan
Peptide accession
P26885
Residue number A
42
Residue number B
97
Peptide name
Peptidyl-prolyl cis-trans isomerase FKBP2

Ligandability

Cysteine 42 of Peptidyl-prolyl cis-trans isomerase FKBP2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 97 of Peptidyl-prolyl cis-trans isomerase FKBP2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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