ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Hepatocyte growth factor-like protein

Intramolecular
Cysteine 468 and cysteine 588
Cysteine 602 and cysteine 667
Cysteine 527 and cysteine 562
Cysteine 657 and cysteine 685
Cysteine 632 and cysteine 646
Cysteine 507 and cysteine 523
A redox-regulated disulphide may form within Hepatocyte growth factor-like protein between cysteines 468 and 588.

Details

Redox score ?
84
PDB code
4qt8
Structure name
crystal structure of ron sema-psi-ipt1 extracellular domains in complex with msp beta-chain
Structure deposition date
2014-07-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
P26927
Residue number A
468
Residue number B
588
Peptide name
Hepatocyte growth factor-like protein

Ligandability

Cysteine 468 of Hepatocyte growth factor-like protein

Cysteine 588 of Hepatocyte growth factor-like protein

A redox-regulated disulphide may form within Hepatocyte growth factor-like protein between cysteines 602 and 667.

Details

Redox score ?
83
PDB code
2asu
Structure name
crystal structure of the beta-chain of hgfl/msp
Structure deposition date
2005-08-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
P26927
Residue number A
602
Residue number B
667
Peptide name
Hepatocyte growth factor-like protein

Ligandability

Cysteine 602 of Hepatocyte growth factor-like protein

Cysteine 667 of Hepatocyte growth factor-like protein

A redox-regulated disulphide may form within Hepatocyte growth factor-like protein between cysteines 527 and 562.

Details

Redox score ?
82
PDB code
4qt8
Structure name
crystal structure of ron sema-psi-ipt1 extracellular domains in complex with msp beta-chain
Structure deposition date
2014-07-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P26927
Residue number A
527
Residue number B
562
Peptide name
Hepatocyte growth factor-like protein

Ligandability

Cysteine 527 of Hepatocyte growth factor-like protein

Cysteine 562 of Hepatocyte growth factor-like protein

A redox-regulated disulphide may form within Hepatocyte growth factor-like protein between cysteines 657 and 685.

Details

Redox score ?
81
PDB code
2asu
Structure name
crystal structure of the beta-chain of hgfl/msp
Structure deposition date
2005-08-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P26927
Residue number A
657
Residue number B
685
Peptide name
Hepatocyte growth factor-like protein

Ligandability

Cysteine 657 of Hepatocyte growth factor-like protein

Cysteine 685 of Hepatocyte growth factor-like protein

A redox-regulated disulphide may form within Hepatocyte growth factor-like protein between cysteines 632 and 646.

Details

Redox score ?
80
PDB code
2asu
Structure name
crystal structure of the beta-chain of hgfl/msp
Structure deposition date
2005-08-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
P26927
Residue number A
632
Residue number B
646
Peptide name
Hepatocyte growth factor-like protein

Ligandability

Cysteine 632 of Hepatocyte growth factor-like protein

Cysteine 646 of Hepatocyte growth factor-like protein

A redox-regulated disulphide may form within Hepatocyte growth factor-like protein between cysteines 507 and 523.

Details

Redox score ?
80
PDB code
4qt8
Structure name
crystal structure of ron sema-psi-ipt1 extracellular domains in complex with msp beta-chain
Structure deposition date
2014-07-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
P26927
Residue number A
507
Residue number B
523
Peptide name
Hepatocyte growth factor-like protein

Ligandability

Cysteine 507 of Hepatocyte growth factor-like protein

Cysteine 523 of Hepatocyte growth factor-like protein

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