ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Activin receptor type-2A

Intramolecular
Cysteine 85 and cysteine 104
Cysteine 91 and cysteine 103
Cysteine 50 and cysteine 78
Cysteine 30 and cysteine 60
Cysteine 30 and cysteine 50
Cysteine 105 and cysteine 110
Cysteine 60 and cysteine 110
Cysteine 30 and cysteine 78
Cysteine 91 and cysteine 105
Cysteine 30 and cysteine 110
More...
Cysteine 50 and cysteine 60
Cysteine 91 and cysteine 110
Cysteine 60 and cysteine 105
Cysteine 85 and cysteine 105
Cysteine 60 and cysteine 78
Cysteine 91 and cysteine 104
Cysteine 30 and cysteine 105
Cysteine 103 and cysteine 105
Cysteine 85 and cysteine 91
Cysteine 85 and cysteine 103
Cysteine 103 and cysteine 104
Cysteine 50 and cysteine 110
Cysteine 60 and cysteine 91
Cysteine 85 and cysteine 110
Cysteine 103 and cysteine 110
Cysteine 30 and cysteine 91
Cysteine 290 and cysteine 401
Cysteine 104 and cysteine 110
Cysteine 78 and cysteine 110
Cysteine 60 and cysteine 85
Cysteine 461 and cysteine 474
Cysteine 60 and cysteine 104
Cysteine 50 and cysteine 105
Cysteine 30 and cysteine 104
Cysteine 104 and cysteine 105
Cysteine 60 and cysteine 103
Cysteine 401 and cysteine 455
A redox-regulated disulphide may form within Activin receptor type-2A between cysteines 85 and 104 (66 and 85 respectively in this structure).

Details

Redox score ?
84
PDB code
1bte
Structure name
crystal structure of the extracellular domain of the type ii activin receptor
Structure deposition date
1998-09-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P27038
Residue number A
85
Residue number B
104
Peptide name
Activin receptor type-2A

Ligandability

Cysteine 85 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 104 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Activin receptor type-2A between cysteines 91 and 103.

Details

Redox score ?
82
PDB code
7u5p
Structure name
crystal structure of the activin receptor type-2a ligand binding domain in complex with activin-a
Structure deposition date
2022-03-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
P27037
Residue number A
91
Residue number B
103
Peptide name
Activin receptor type-2A

Ligandability

Cysteine 91 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 103 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Activin receptor type-2A between cysteines 50 and 78.

Details

Redox score ?
82
PDB code
7u5p
Structure name
crystal structure of the activin receptor type-2a ligand binding domain in complex with activin-a
Structure deposition date
2022-03-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
P27037
Residue number A
50
Residue number B
78
Peptide name
Activin receptor type-2A

Ligandability

Cysteine 50 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 78 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Activin receptor type-2A between cysteines 30 and 60 (11 and 41 respectively in this structure).

Details

Redox score ?
82
PDB code
1bte
Structure name
crystal structure of the extracellular domain of the type ii activin receptor
Structure deposition date
1998-09-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide accession
P27038
Residue number A
30
Residue number B
60
Peptide name
Activin receptor type-2A

Ligandability

Cysteine 30 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 60 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Activin receptor type-2A between cysteines 30 and 50.

Details

Redox score ?
81
PDB code
5nh3
Structure name
crystal structure of the activin receptor type-2a ligand binding domain in complex with bimagrumab fv
Structure deposition date
2017-03-21
Thiol separation (Å)
3
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
P27037
Residue number A
30
Residue number B
50
Peptide name
Activin receptor type-2A

Ligandability

Cysteine 30 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 50 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Activin receptor type-2A between cysteines 105 and 110.

Details

Redox score ?
77
PDB code
7u5p
Structure name
crystal structure of the activin receptor type-2a ligand binding domain in complex with activin-a
Structure deposition date
2022-03-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
P27037
Residue number A
105
Residue number B
110
Peptide name
Activin receptor type-2A

Ligandability

Cysteine 105 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 110 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Activin receptor type-2A between cysteines 60 and 110 (41 and 91 respectively in this structure).

Details

Redox score ?
74
PDB code
2goo
Structure name
ternary complex of bmp-2 bound to bmpr-ia-ecd and actrii-ecd
Structure deposition date
2006-04-13
Thiol separation (Å)
3
Half-sphere exposure sum ?
84
Minimum pKa ?
7
% buried
nan
Peptide accession
P27038
Residue number A
60
Residue number B
110
Peptide name
Activin receptor type-2A

Ligandability

Cysteine 60 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 110 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Activin receptor type-2A between cysteines 30 and 78 (11 and 59 respectively in this structure).

Details

Redox score ?
70
PDB code
2goo
Structure name
ternary complex of bmp-2 bound to bmpr-ia-ecd and actrii-ecd
Structure deposition date
2006-04-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
P27038
Residue number A
30
Residue number B
78
Peptide name
Activin receptor type-2A

Ligandability

Cysteine 30 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 78 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Activin receptor type-2A between cysteines 91 and 105.

Details

Redox score ?
70
PDB code
7u5p
Structure name
crystal structure of the activin receptor type-2a ligand binding domain in complex with activin-a
Structure deposition date
2022-03-02
Thiol separation (Å)
4
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
P27037
Residue number A
91
Residue number B
105
Peptide name
Activin receptor type-2A

Ligandability

Cysteine 91 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 105 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Activin receptor type-2A between cysteines 30 and 110 (11 and 91 respectively in this structure).

Details

Redox score ?
67
PDB code
2goo
Structure name
ternary complex of bmp-2 bound to bmpr-ia-ecd and actrii-ecd
Structure deposition date
2006-04-13
Thiol separation (Å)
5
Half-sphere exposure sum ?
70
Minimum pKa ?
7
% buried
nan
Peptide accession
P27038
Residue number A
30
Residue number B
110
Peptide name
Activin receptor type-2A

Ligandability

Cysteine 30 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 110 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Activin receptor type-2A between cysteines 50 and 60.

Details

Redox score ?
66
PDB code
5nh3
Structure name
crystal structure of the activin receptor type-2a ligand binding domain in complex with bimagrumab fv
Structure deposition date
2017-03-21
Thiol separation (Å)
5
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
P27037
Residue number A
50
Residue number B
60
Peptide name
Activin receptor type-2A

Ligandability

Cysteine 50 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 60 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Activin receptor type-2A between cysteines 91 and 110.

Details

Redox score ?
61
PDB code
7u5p
Structure name
crystal structure of the activin receptor type-2a ligand binding domain in complex with activin-a
Structure deposition date
2022-03-02
Thiol separation (Å)
6
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
P27037
Residue number A
91
Residue number B
110
Peptide name
Activin receptor type-2A

Ligandability

Cysteine 91 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 110 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Activin receptor type-2A between cysteines 60 and 105. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
5nh3
Structure name
crystal structure of the activin receptor type-2a ligand binding domain in complex with bimagrumab fv
Structure deposition date
2017-03-21
Thiol separation (Å)
5
Half-sphere exposure sum ?
96
Minimum pKa ?
nan
% buried
nan
Peptide accession
P27037
Residue number A
60
Residue number B
105
Peptide name
Activin receptor type-2A

Ligandability

Cysteine 60 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 105 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Activin receptor type-2A between cysteines 85 and 105 (66 and 86 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
1bte
Structure name
crystal structure of the extracellular domain of the type ii activin receptor
Structure deposition date
1998-09-01
Thiol separation (Å)
7
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P27038
Residue number A
85
Residue number B
105
Peptide name
Activin receptor type-2A

Ligandability

Cysteine 85 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 105 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Activin receptor type-2A between cysteines 60 and 78. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
5nh3
Structure name
crystal structure of the activin receptor type-2a ligand binding domain in complex with bimagrumab fv
Structure deposition date
2017-03-21
Thiol separation (Å)
6
Half-sphere exposure sum ?
100
Minimum pKa ?
nan
% buried
nan
Peptide accession
P27037
Residue number A
60
Residue number B
78
Peptide name
Activin receptor type-2A

Ligandability

Cysteine 60 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 78 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Activin receptor type-2A between cysteines 91 and 104. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
7u5p
Structure name
crystal structure of the activin receptor type-2a ligand binding domain in complex with activin-a
Structure deposition date
2022-03-02
Thiol separation (Å)
7
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
P27037
Residue number A
91
Residue number B
104
Peptide name
Activin receptor type-2A

Ligandability

Cysteine 91 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 104 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Activin receptor type-2A between cysteines 30 and 105. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
7u5p
Structure name
crystal structure of the activin receptor type-2a ligand binding domain in complex with activin-a
Structure deposition date
2022-03-02
Thiol separation (Å)
7
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
P27037
Residue number A
30
Residue number B
105
Peptide name
Activin receptor type-2A

Ligandability

Cysteine 30 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 105 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Activin receptor type-2A between cysteines 103 and 105. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
5nh3
Structure name
crystal structure of the activin receptor type-2a ligand binding domain in complex with bimagrumab fv
Structure deposition date
2017-03-21
Thiol separation (Å)
6
Half-sphere exposure sum ?
86
Minimum pKa ?
nan
% buried
nan
Peptide accession
P27037
Residue number A
103
Residue number B
105
Peptide name
Activin receptor type-2A

Ligandability

Cysteine 103 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 105 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Activin receptor type-2A between cysteines 85 and 91. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
7u5p
Structure name
crystal structure of the activin receptor type-2a ligand binding domain in complex with activin-a
Structure deposition date
2022-03-02
Thiol separation (Å)
8
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P27037
Residue number A
85
Residue number B
91
Peptide name
Activin receptor type-2A

Ligandability

Cysteine 85 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 91 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Activin receptor type-2A between cysteines 85 and 103 (66 and 84 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
1bte
Structure name
crystal structure of the extracellular domain of the type ii activin receptor
Structure deposition date
1998-09-01
Thiol separation (Å)
8
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P27038
Residue number A
85
Residue number B
103
Peptide name
Activin receptor type-2A

Ligandability

Cysteine 85 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 103 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Activin receptor type-2A between cysteines 103 and 104 (84 and 85 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
1lx5
Structure name
crystal structure of the bmp7/actrii extracellular domain complex
Structure deposition date
2002-06-04
Thiol separation (Å)
7
Half-sphere exposure sum ?
95
Minimum pKa ?
nan
% buried
nan
Peptide accession
P27038
Residue number A
103
Residue number B
104
Peptide name
Activin receptor type-2A

Ligandability

Cysteine 103 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 104 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Activin receptor type-2A between cysteines 50 and 110 (31 and 91 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
1lx5
Structure name
crystal structure of the bmp7/actrii extracellular domain complex
Structure deposition date
2002-06-04
Thiol separation (Å)
8
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P27038
Residue number A
50
Residue number B
110
Peptide name
Activin receptor type-2A

Ligandability

Cysteine 50 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 110 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Activin receptor type-2A between cysteines 60 and 91. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
5nh3
Structure name
crystal structure of the activin receptor type-2a ligand binding domain in complex with bimagrumab fv
Structure deposition date
2017-03-21
Thiol separation (Å)
8
Half-sphere exposure sum ?
88
Minimum pKa ?
nan
% buried
nan
Peptide accession
P27037
Residue number A
60
Residue number B
91
Peptide name
Activin receptor type-2A

Ligandability

Cysteine 60 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 91 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Activin receptor type-2A between cysteines 85 and 110 (66 and 91 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
1lx5
Structure name
crystal structure of the bmp7/actrii extracellular domain complex
Structure deposition date
2002-06-04
Thiol separation (Å)
8
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P27038
Residue number A
85
Residue number B
110
Peptide name
Activin receptor type-2A

Ligandability

Cysteine 85 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 110 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Activin receptor type-2A between cysteines 103 and 110. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
5nh3
Structure name
crystal structure of the activin receptor type-2a ligand binding domain in complex with bimagrumab fv
Structure deposition date
2017-03-21
Thiol separation (Å)
8
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
P27037
Residue number A
103
Residue number B
110
Peptide name
Activin receptor type-2A

Ligandability

Cysteine 103 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 110 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Activin receptor type-2A between cysteines 30 and 91. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
7u5p
Structure name
crystal structure of the activin receptor type-2a ligand binding domain in complex with activin-a
Structure deposition date
2022-03-02
Thiol separation (Å)
9
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
P27037
Residue number A
30
Residue number B
91
Peptide name
Activin receptor type-2A

Ligandability

Cysteine 30 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 91 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Activin receptor type-2A between cysteines 290 and 401. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
3q4t
Structure name
crystal structure of activin receptor type-iia (acvr2a) kinase domain in complex with dorsomorphin
Structure deposition date
2010-12-24
Thiol separation (Å)
8
Half-sphere exposure sum ?
75
Minimum pKa ?
11
% buried
88
Peptide accession
P27037
Residue number A
290
Residue number B
401
Peptide name
Activin receptor type-2A

Ligandability

Cysteine 290 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 401 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Activin receptor type-2A between cysteines 104 and 110. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
5nh3
Structure name
crystal structure of the activin receptor type-2a ligand binding domain in complex with bimagrumab fv
Structure deposition date
2017-03-21
Thiol separation (Å)
8
Half-sphere exposure sum ?
86
Minimum pKa ?
nan
% buried
nan
Peptide accession
P27037
Residue number A
104
Residue number B
110
Peptide name
Activin receptor type-2A

Ligandability

Cysteine 104 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 110 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Activin receptor type-2A between cysteines 78 and 110 (59 and 91 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
2goo
Structure name
ternary complex of bmp-2 bound to bmpr-ia-ecd and actrii-ecd
Structure deposition date
2006-04-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
82
Minimum pKa ?
7
% buried
nan
Peptide accession
P27038
Residue number A
78
Residue number B
110
Peptide name
Activin receptor type-2A

Ligandability

Cysteine 78 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 110 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Activin receptor type-2A between cysteines 60 and 85. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
7u5p
Structure name
crystal structure of the activin receptor type-2a ligand binding domain in complex with activin-a
Structure deposition date
2022-03-02
Thiol separation (Å)
10
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
P27037
Residue number A
60
Residue number B
85
Peptide name
Activin receptor type-2A

Ligandability

Cysteine 60 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 85 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Activin receptor type-2A between cysteines 461 and 474. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
3soc
Structure name
crystal structure of activin receptor type-iia (acvr2a) kinase domain in complex with a quinazolin
Structure deposition date
2011-06-30
Thiol separation (Å)
10
Half-sphere exposure sum ?
61
Minimum pKa ?
9
% buried
59
Peptide accession
P27037
Residue number A
461
Residue number B
474
Peptide name
Activin receptor type-2A

Ligandability

Cysteine 461 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 474 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Activin receptor type-2A between cysteines 60 and 104 (41 and 85 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
1lx5
Structure name
crystal structure of the bmp7/actrii extracellular domain complex
Structure deposition date
2002-06-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
98
Minimum pKa ?
nan
% buried
nan
Peptide accession
P27038
Residue number A
60
Residue number B
104
Peptide name
Activin receptor type-2A

Ligandability

Cysteine 60 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 104 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Activin receptor type-2A between cysteines 50 and 105. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
5nh3
Structure name
crystal structure of the activin receptor type-2a ligand binding domain in complex with bimagrumab fv
Structure deposition date
2017-03-21
Thiol separation (Å)
10
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
P27037
Residue number A
50
Residue number B
105
Peptide name
Activin receptor type-2A

Ligandability

Cysteine 50 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 105 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Activin receptor type-2A between cysteines 30 and 104 (11 and 85 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
1lx5
Structure name
crystal structure of the bmp7/actrii extracellular domain complex
Structure deposition date
2002-06-04
Thiol separation (Å)
10
Half-sphere exposure sum ?
86
Minimum pKa ?
nan
% buried
nan
Peptide accession
P27038
Residue number A
30
Residue number B
104
Peptide name
Activin receptor type-2A

Ligandability

Cysteine 30 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 104 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Activin receptor type-2A between cysteines 104 and 105 (85 and 86 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
2goo
Structure name
ternary complex of bmp-2 bound to bmpr-ia-ecd and actrii-ecd
Structure deposition date
2006-04-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
89
Minimum pKa ?
16
% buried
nan
Peptide accession
P27038
Residue number A
104
Residue number B
105
Peptide name
Activin receptor type-2A

Ligandability

Cysteine 104 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 105 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Activin receptor type-2A between cysteines 60 and 103. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
7u5p
Structure name
crystal structure of the activin receptor type-2a ligand binding domain in complex with activin-a
Structure deposition date
2022-03-02
Thiol separation (Å)
10
Half-sphere exposure sum ?
92
Minimum pKa ?
nan
% buried
nan
Peptide accession
P27037
Residue number A
60
Residue number B
103
Peptide name
Activin receptor type-2A

Ligandability

Cysteine 60 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 103 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Activin receptor type-2A between cysteines 401 and 455. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
4asx
Structure name
crystal structure of activin receptor type-iia (acvr2a) kinase domain in complex with dihydro-bauerine c
Structure deposition date
2012-05-03
Thiol separation (Å)
10
Half-sphere exposure sum ?
71
Minimum pKa ?
11
% buried
74
Peptide accession
P27037
Residue number A
401
Residue number B
455
Peptide name
Activin receptor type-2A

Ligandability

Cysteine 401 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 455 of Activin receptor type-2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: