ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Amine oxidase [flavin-containing] B

Intramolecular
Cysteine 389 and cysteine 397
Cysteine 172 and cysteine 192
A redox-regulated disulphide may form within Amine oxidase [flavin-containing] B between cysteines 389 and 397. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
6rkb
Structure name
crystal structure of human monoamine oxidase b in complex with styrylpiperidine analogue 1
Structure deposition date
2019-04-30
Thiol separation (Å)
9
Half-sphere exposure sum ?
88
Minimum pKa ?
11
% buried
100
Peptide accession
P27338
Residue number A
389
Residue number B
397
Peptide name
Amine oxidase [flavin-containing] B

Ligandability

Cysteine 389 of Amine oxidase [flavin-containing] B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 397 of Amine oxidase [flavin-containing] B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Amine oxidase [flavin-containing] B between cysteines 172 and 192. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
7p4f
Structure name
crystal structure of monoamine oxidase b in complex with inhibitor 1
Structure deposition date
2021-07-11
Thiol separation (Å)
8
Half-sphere exposure sum ?
79
Minimum pKa ?
13
% buried
100
Peptide accession
P27338
Residue number A
172
Residue number B
192
Peptide name
Amine oxidase [flavin-containing] B

Ligandability

Cysteine 172 of Amine oxidase [flavin-containing] B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 192 of Amine oxidase [flavin-containing] B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: