ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Dipeptidyl peptidase 4

Intramolecular
Cysteine 385 and cysteine 394
Cysteine 444 and cysteine 447
Cysteine 328 and cysteine 339
Cysteine 454 and cysteine 472
Cysteine 649 and cysteine 762
Cysteine 299 and cysteine 352
A redox-regulated disulphide may form within Dipeptidyl peptidase 4 between cysteines 385 and 394.

Details

Redox score ?
86
PDB code
1r9m
Structure name
crystal structure of human dipeptidyl peptidase iv at 2
Structure deposition date
2003-10-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P27487
Residue number A
385
Residue number B
394
Peptide name
Dipeptidyl peptidase 4

Ligandability

Cysteine 385 of Dipeptidyl peptidase 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 394 of Dipeptidyl peptidase 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dipeptidyl peptidase 4 between cysteines 444 and 447.

Details

Redox score ?
86
PDB code
2hha
Structure name
the structure of dpp4 in complex with an oxadiazole inhibitor
Structure deposition date
2006-06-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q53TN1
Residue number A
444
Residue number B
447
Peptide name
Dipeptidyl peptidase 4

Ligandability

Cysteine 444 of Dipeptidyl peptidase 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 447 of Dipeptidyl peptidase 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dipeptidyl peptidase 4 between cysteines 328 and 339.

Details

Redox score ?
83
PDB code
2hha
Structure name
the structure of dpp4 in complex with an oxadiazole inhibitor
Structure deposition date
2006-06-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q53TN1
Residue number A
328
Residue number B
339
Peptide name
Dipeptidyl peptidase 4

Ligandability

Cysteine 328 of Dipeptidyl peptidase 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 339 of Dipeptidyl peptidase 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dipeptidyl peptidase 4 between cysteines 454 and 472.

Details

Redox score ?
83
PDB code
2hha
Structure name
the structure of dpp4 in complex with an oxadiazole inhibitor
Structure deposition date
2006-06-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q53TN1
Residue number A
454
Residue number B
472
Peptide name
Dipeptidyl peptidase 4

Ligandability

Cysteine 454 of Dipeptidyl peptidase 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 472 of Dipeptidyl peptidase 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dipeptidyl peptidase 4 between cysteines 649 and 762.

Details

Redox score ?
82
PDB code
2hha
Structure name
the structure of dpp4 in complex with an oxadiazole inhibitor
Structure deposition date
2006-06-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q53TN1
Residue number A
649
Residue number B
762
Peptide name
Dipeptidyl peptidase 4

Ligandability

Cysteine 649 of Dipeptidyl peptidase 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 762 of Dipeptidyl peptidase 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dipeptidyl peptidase 4 between cysteines 299 and 352. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
4ffv
Structure name
crystal structure of dipeptidyl peptidase iv (dpp4, dpp-iv, cd26) in complex with 11a19 fab
Structure deposition date
2012-06-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
80
Minimum pKa ?
12
% buried
94
Peptide accession
P14740
Residue number A
299
Residue number B
352
Peptide name
Dipeptidyl peptidase 4

Ligandability

Cysteine 299 of Dipeptidyl peptidase 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 352 of Dipeptidyl peptidase 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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