ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

cAMP-specific 3',5'-cyclic phosphodiesterase 4A

Intramolecular
Cysteine 817 and cysteine 222
A redox-regulated disulphide may form within cAMP-specific 3',5'-cyclic phosphodiesterase 4A between cysteines 817 and 222 (8 and 11 respectively in this structure).

Details

Redox score ?
60
PDB code
1loi
Structure name
n-terminal splice region of rat c-amp phosphodiesterase, nmr, 7 structures
Structure deposition date
1996-05-21
Thiol separation (Å)
7
Half-sphere exposure sum ?
28
Minimum pKa ?
9
% buried
0
Peptide accession
P54748
Residue number A
817
Residue number B
222
Peptide name
cAMP-specific 3',5'-cyclic phosphodiesterase 4A

Ligandability

Cysteine 817 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A

Cysteine 222 of cAMP-specific 3',5'-cyclic phosphodiesterase 4A

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