ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Calnexin

Intramolecular
Cysteine 361 and cysteine 367 L
Cysteine 161 and cysteine 195
A redox-regulated disulphide may form within Calnexin between cysteines 361 and 367.

Details

Redox score ?
87
PDB code
1jhn
Structure name
crystal structure of the lumenal domain of calnexin
Structure deposition date
2001-06-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
P24643
Residue number A
361
Residue number B
367
Peptide name
Calnexin

Ligandability

Cysteine 361 of Calnexin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 367 of Calnexin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Calnexin between cysteines 161 and 195.

Details

Redox score ?
85
PDB code
1jhn
Structure name
crystal structure of the lumenal domain of calnexin
Structure deposition date
2001-06-28
Thiol separation (Å)
3
Half-sphere exposure sum ?
48
Minimum pKa ?
9
% buried
0
Peptide accession
P24643
Residue number A
161
Residue number B
195
Peptide name
Calnexin

Ligandability

Cysteine 161 of Calnexin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 195 of Calnexin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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