a tool for identifying drug-targetable redox-active disulphides

Interleukin-1 receptor type 2

Intramolecular

Cysteine 28 and cysteine 116

Cysteine 258 and cysteine 326

Cysteine 152 and cysteine 207

Cysteine 50 and cysteine 108

A redox-regulated disulphide may form within Interleukin-1 receptor type 2 between cysteines 28 and 116 (15 and 103 respectively in this structure).

Details

Redox score ?

92

PDB code

Structure name

crystal structure of an interleukin-1 receptor complex

Structure deposition date

2010-07-27

Thiol separation (Å)

2

Half-sphere exposure sum ?

nan

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

28

Residue number B

116

Peptide name

Interleukin-1 receptor type 2

Ligandability

Cysteine 28 of Interleukin-1 receptor type 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 116 of Interleukin-1 receptor type 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-1 receptor type 2 between cysteines 258 and 326 (245 and 313 respectively in this structure).

Details

Redox score ?

82

PDB code

Structure name

crystal structure of an interleukin-1 receptor complex

Structure deposition date

2010-07-27

Thiol separation (Å)

2

Half-sphere exposure sum ?

75

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

258

Residue number B

326

Peptide name

Interleukin-1 receptor type 2

Ligandability

Cysteine 258 of Interleukin-1 receptor type 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 326 of Interleukin-1 receptor type 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-1 receptor type 2 between cysteines 152 and 207 (139 and 194 respectively in this structure).

Details

Redox score ?

81

PDB code

Structure name

crystal structure of an interleukin-1 receptor complex

Structure deposition date

2010-07-27

Thiol separation (Å)

2

Half-sphere exposure sum ?

84

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

152

Residue number B

207

Peptide name

Interleukin-1 receptor type 2

Ligandability

Cysteine 152 of Interleukin-1 receptor type 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 207 of Interleukin-1 receptor type 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-1 receptor type 2 between cysteines 50 and 108 (37 and 95 respectively in this structure).

Details

Redox score ?

80

PDB code

Structure name

crystal structure of an interleukin-1 receptor complex

Structure deposition date

2010-07-27

Thiol separation (Å)

2

Half-sphere exposure sum ?

78

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

50

Residue number B

108

Peptide name

Interleukin-1 receptor type 2

Ligandability

Cysteine 50 of Interleukin-1 receptor type 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 108 of Interleukin-1 receptor type 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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