ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Phosphatidylinositol 3-kinase regulatory subunit alpha

Intramolecular
Cysteine 659 and cysteine 670
Cysteine 656 and cysteine 659
A redox-regulated disulphide may form within Phosphatidylinositol 3-kinase regulatory subunit alpha between cysteines 659 and 670 (46 and 57 respectively in this structure).

Details

Redox score ?
65
PDB code
1qad
Structure name
crystal structure of the c-terminal sh2 domain of the p85 alpha regulatory subunit of phosphoinositide 3-kinase: an sh2 domain mimicking its own substrate
Structure deposition date
1999-02-26
Thiol separation (Å)
5
Half-sphere exposure sum ?
72
Minimum pKa ?
8
% buried
92
Peptide accession
P23727
Residue number A
659
Residue number B
670
Peptide name
Phosphatidylinositol 3-kinase regulatory subunit alpha

Ligandability

Cysteine 659 of Phosphatidylinositol 3-kinase regulatory subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 670 of Phosphatidylinositol 3-kinase regulatory subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Phosphatidylinositol 3-kinase regulatory subunit alpha between cysteines 656 and 659 (43 and 46 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
1bfi
Structure name
solution structure of the c-terminal sh2 domain of the p85alpha regulatory subunit of phosphoinositide 3-kinase, nmr, 30 structures
Structure deposition date
1997-11-18
Thiol separation (Å)
10
Half-sphere exposure sum ?
59
Minimum pKa ?
9
% buried
50
Peptide accession
P23727
Residue number A
656
Residue number B
659
Peptide name
Phosphatidylinositol 3-kinase regulatory subunit alpha

Ligandability

Cysteine 656 of Phosphatidylinositol 3-kinase regulatory subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 659 of Phosphatidylinositol 3-kinase regulatory subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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