a tool for identifying drug-targetable redox-active disulphides

Proteasome subunit beta type-8

Intramolecular

Cysteine 120 and cysteine 124 L

A redox-regulated disulphide may form within Proteasome subunit beta type-8 between cysteines 120 and 124 (48 and 52 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

47

PDB code

Structure name

human immunoproteasome 20s particle in complex with [2-(3- ethylphenyl)-1-[(2s)-3-phenyl-2-[(pyrazin-2-yl) formamido]propanamido]ethyl]boronic acid

Structure deposition date

2020-11-23

Thiol separation (Å)

7

Half-sphere exposure sum ?

71

Minimum pK_a ?

11

% buried

90

Peptide accession

Residue number A

120

Residue number B

124

Peptide name

Proteasome subunit beta type-8

Ligandability

Cysteine 120 of Proteasome subunit beta type-8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 124 of Proteasome subunit beta type-8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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