ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

HLA class II histocompatibility antigen, DM alpha chain

Intramolecular
Cysteine 50 and cysteine 105
Cysteine 147 and cysteine 202
A redox-regulated disulphide may form within HLA class II histocompatibility antigen, DM alpha chain between cysteines 50 and 105 (24 and 77 respectively in this structure).

Details

Redox score ?
81
PDB code
1hdm
Structure name
histocompatibility antigen hla-dm
Structure deposition date
1998-09-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
P28067
Residue number A
50
Residue number B
105
Peptide name
HLA class II histocompatibility antigen, DM alpha chain

Ligandability

Cysteine 50 of HLA class II histocompatibility antigen, DM alpha chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 105 of HLA class II histocompatibility antigen, DM alpha chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within HLA class II histocompatibility antigen, DM alpha chain between cysteines 147 and 202 (121 and 176 respectively in this structure).

Details

Redox score ?
79
PDB code
4fqx
Structure name
crystal structure of hla-dm bound to hla-dr1
Structure deposition date
2012-06-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
P28067
Residue number A
147
Residue number B
202
Peptide name
HLA class II histocompatibility antigen, DM alpha chain

Ligandability

Cysteine 147 of HLA class II histocompatibility antigen, DM alpha chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 202 of HLA class II histocompatibility antigen, DM alpha chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: