ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Proteasome subunit beta type-6

Intramolecular
Cysteine 77 and cysteine 78
Cysteine 77 and cysteine 121
A redox-regulated disulphide may form within Proteasome subunit beta type-6 between cysteines 77 and 78 (43 and 44 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
5lex
Structure name
native human 20s proteasome in mg-acetate at 2
Structure deposition date
2016-06-30
Thiol separation (Å)
7
Half-sphere exposure sum ?
101
Minimum pKa ?
11
% buried
100
Peptide accession
P28072
Residue number A
77
Residue number B
78
Peptide name
Proteasome subunit beta type-6

Ligandability

Cysteine 77 of Proteasome subunit beta type-6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 78 of Proteasome subunit beta type-6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proteasome subunit beta type-6 between cysteines 77 and 121 (44 and 88 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
5lf4
Structure name
human 20s proteasome complex with delanzomib at 2
Structure deposition date
2016-06-30
Thiol separation (Å)
9
Half-sphere exposure sum ?
85
Minimum pKa ?
12
% buried
100
Peptide accession
P28072
Residue number A
77
Residue number B
121
Peptide name
Proteasome subunit beta type-6

Ligandability

Cysteine 77 of Proteasome subunit beta type-6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 121 of Proteasome subunit beta type-6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: