ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Proteasome subunit beta type-5

Intramolecular
Cysteine 48 and cysteine 111
A redox-regulated disulphide may form within Proteasome subunit beta type-5 between cysteines 48 and 111 (48 and 52 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
3unf
Structure name
mouse 20s immunoproteasome in complex with pr-957
Structure deposition date
2011-11-15
Thiol separation (Å)
7
Half-sphere exposure sum ?
69
Minimum pKa ?
12
% buried
90
Peptide accession
O55234
Residue number A
48
Residue number B
111
Peptide name
Proteasome subunit beta type-5

Ligandability

Cysteine 48 of Proteasome subunit beta type-5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 111 of Proteasome subunit beta type-5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 48 in protein A could not be asigned to a Uniprot residue.
If this tool was useful for finding a disulphide, please cite: