ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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5-hydroxytryptamine receptor 1D

Intramolecular
Cysteine 327 and cysteine 331
Cysteine 111 and cysteine 188
Cysteine 121 and cysteine 122
A redox-regulated disulphide may form within 5-hydroxytryptamine receptor 1D between cysteines 327 and 331.

Details

Redox score ?
89
PDB code
7e32
Structure name
serotonin 1d (5-ht1d) receptor-gi protein complex
Structure deposition date
2021-02-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
28
Minimum pKa ?
nan
% buried
nan
Peptide accession
P28221
Residue number A
327
Residue number B
331
Peptide name
5-hydroxytryptamine receptor 1D

Ligandability

Cysteine 327 of 5-hydroxytryptamine receptor 1D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 331 of 5-hydroxytryptamine receptor 1D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 5-hydroxytryptamine receptor 1D between cysteines 111 and 188.

Details

Redox score ?
87
PDB code
7e32
Structure name
serotonin 1d (5-ht1d) receptor-gi protein complex
Structure deposition date
2021-02-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
P28221
Residue number A
111
Residue number B
188
Peptide name
5-hydroxytryptamine receptor 1D

Ligandability

Cysteine 111 of 5-hydroxytryptamine receptor 1D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 188 of 5-hydroxytryptamine receptor 1D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 5-hydroxytryptamine receptor 1D between cysteines 121 and 122. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
7e32
Structure name
serotonin 1d (5-ht1d) receptor-gi protein complex
Structure deposition date
2021-02-07
Thiol separation (Å)
7
Half-sphere exposure sum ?
90
Minimum pKa ?
11
% buried
90
Peptide accession
P28221
Residue number A
121
Residue number B
122
Peptide name
5-hydroxytryptamine receptor 1D

Ligandability

Cysteine 121 of 5-hydroxytryptamine receptor 1D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 122 of 5-hydroxytryptamine receptor 1D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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