5-hydroxytryptamine receptor 1B

Intramolecular

A redox-regulated disulphide may form within 5-hydroxytryptamine receptor 1B between cysteines 340 and 344 (380 and 384 respectively in this structure).

Details

Redox score ?

PDB code

7c61

Structure name

crystal structure of 5-ht1b-bril and srp2070_fab complex

Structure deposition date

2020-05-21

Thiol separation (Å)

Half-sphere exposure sum ?

nan

Minimum pK_a ?

nan

% buried

nan

Peptide accession

P28222

Residue number A

340

Residue number B

344

Peptide name

5-hydroxytryptamine receptor 1B

Ligandability

Cysteine 340 of 5-hydroxytryptamine receptor 1B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 344 of 5-hydroxytryptamine receptor 1B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 5-hydroxytryptamine receptor 1B between cysteines 122 and 199.

Details

Redox score ?

PDB code

5v54

Structure name

crystal structure of 5-ht1b receptor in complex with methiothepin

Structure deposition date

2017-03-13

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

nan

% buried

nan

Peptide accession

P28222

Residue number A

122

Residue number B

199

Peptide name

5-hydroxytryptamine receptor 1B

Ligandability

Cysteine 122 of 5-hydroxytryptamine receptor 1B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 199 of 5-hydroxytryptamine receptor 1B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 5-hydroxytryptamine receptor 1B between cysteines 132 and 133. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?