ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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5-hydroxytryptamine receptor 2A

Intramolecular
Cysteine 349 and cysteine 353
Cysteine 148 and cysteine 227
A redox-regulated disulphide may form within 5-hydroxytryptamine receptor 2A between cysteines 349 and 353.

Details

Redox score ?
89
PDB code
6wh4
Structure name
crystal structure of htr2a with inverse agonist
Structure deposition date
2020-04-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
31
Minimum pKa ?
nan
% buried
nan
Peptide accession
P28223
Residue number A
349
Residue number B
353
Peptide name
5-hydroxytryptamine receptor 2A

Ligandability

Cysteine 349 of 5-hydroxytryptamine receptor 2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 353 of 5-hydroxytryptamine receptor 2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 5-hydroxytryptamine receptor 2A between cysteines 148 and 227.

Details

Redox score ?
82
PDB code
6a94
Structure name
crystal structure of 5-ht2ar in complex with zotepine
Structure deposition date
2018-07-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
P28223
Residue number A
148
Residue number B
227
Peptide name
5-hydroxytryptamine receptor 2A

Ligandability

Cysteine 148 of 5-hydroxytryptamine receptor 2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 227 of 5-hydroxytryptamine receptor 2A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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