ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Cystatin-D

Intramolecular
Cysteine 119 and cysteine 139
Cysteine 95 and cysteine 105
A redox-regulated disulphide may form within Cystatin-D between cysteines 119 and 139 (99 and 119 respectively in this structure).

Details

Redox score ?
88
PDB code
1roa
Structure name
structure of human cystatin d
Structure deposition date
2003-12-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
P28325
Residue number A
119
Residue number B
139
Peptide name
Cystatin-D

Ligandability

Cysteine 119 of Cystatin-D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 139 of Cystatin-D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cystatin-D between cysteines 95 and 105 (75 and 85 respectively in this structure).

Details

Redox score ?
86
PDB code
1rn7
Structure name
structure of human cystatin d
Structure deposition date
2003-11-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
46
Minimum pKa ?
nan
% buried
nan
Peptide accession
P28325
Residue number A
95
Residue number B
105
Peptide name
Cystatin-D

Ligandability

Cysteine 95 of Cystatin-D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 105 of Cystatin-D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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