NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Intermolecular
Cysteine 727 and cysteine 112 of NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
Cysteine 382 of NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial and cysteine 64
Cysteine 382 of NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial and cysteine 75
Cysteine 128 and cysteine 116 of NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
Intramolecular
Cysteine 64 and cysteine 92
Cysteine 64 and cysteine 75
Cysteine 78 and cysteine 92 L
Cysteine 64 and cysteine 78 L
Cysteine 64 and cysteine 179
Cysteine 75 and cysteine 78 L
More...Cysteine 176 and cysteine 226
Cysteine 179 and cysteine 226
Cysteine 128 and cysteine 131
Cysteine 176 and cysteine 179
Cysteine 179 and cysteine 182
Cysteine 131 and cysteine 137
Cysteine 176 and cysteine 182
Cysteine 182 and cysteine 226
Cysteine 137 and cysteine 226
Cysteine 128 and cysteine 137
Cysteine 131 and cysteine 727
Cysteine 75 and cysteine 179
Cysteine 131 and cysteine 226
Cysteine 367 and cysteine 554
Cysteine 53 and cysteine 78 L
Cysteine 75 and cysteine 92
7qso G 704 R 84
A redox-regulated disulphide may form between cysteine 727 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial and cysteine 112 of NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (704 and 84 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
7qso
Structure name
bovine complex i in lipid nanodisc, state 3 (slack)
Structure deposition date
2022-01-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
nan
Minimum pKa ?
10
% buried
nan
Peptide A name
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Peptide B name
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
Peptide A accession
P15690
Peptide B accession
P23934
Peptide A residue number
727
Peptide B residue number
112
Ligandability
Cysteine 727 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Cysteine 112 of NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
5o31 F 362 G 41
A redox-regulated disulphide may form between cysteine 382 of NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial and cysteine 64 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (362 and 41 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
5o31
Structure name
mitochondrial complex i in the deactive state
Structure deposition date
2017-05-23
Thiol separation (Å)
10
Half-sphere exposure sum ?
87
Minimum pKa ?
6
% buried
100
Peptide A name
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
Peptide B name
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Peptide A accession
P25708
Peptide B accession
P15690
Peptide A residue number
382
Peptide B residue number
64
Ligandability
Cysteine 382 of NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
Cysteine 64 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
5xtd A 382 M 75
A redox-regulated disulphide may form between cysteine 382 of NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial and cysteine 75 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
33
PDB code
5xtd
Structure name
cryo-em structure of human respiratory complex i
Structure deposition date
2017-06-19
Thiol separation (Å)
9
Half-sphere exposure sum ?
84
Minimum pKa ?
10
% buried
100
Peptide A name
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
Peptide B name
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Peptide A accession
P49821
Peptide B accession
P28331
Peptide A residue number
382
Peptide B residue number
75
Ligandability
Cysteine 382 of NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
Cysteine 75 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
7dgz A 128 E 116
A redox-regulated disulphide may form between cysteine 128 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial and cysteine 116 of NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
26
PDB code
7dgz
Structure name
activity optimized complex i (closed form)
Structure deposition date
2020-11-12
Thiol separation (Å)
10
Half-sphere exposure sum ?
84
Minimum pKa ?
12
% buried
100
Peptide A name
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Peptide B name
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
Peptide A accession
P15690
Peptide B accession
P42028
Peptide A residue number
128
Peptide B residue number
116
Ligandability
Cysteine 128 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Cysteine 116 of NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
6g2j G 41 G 69
A redox-regulated disulphide may form within NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial between cysteines 64 and 92 (41 and 69 respectively in this structure).
Details
Redox score ?
78
PDB code
6g2j
Structure name
mouse mitochondrial complex i in the active state
Structure deposition date
2018-03-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
85
Minimum pKa ?
3
% buried
100
Peptide accession
Q91VD9
Residue number A
64
Residue number B
92
Peptide name
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Ligandability
Cysteine 64 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Cysteine 92 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
5o31 G 41 G 52
A redox-regulated disulphide may form within NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial between cysteines 64 and 75 (41 and 52 respectively in this structure).
Details
Redox score ?
75
PDB code
5o31
Structure name
mitochondrial complex i in the deactive state
Structure deposition date
2017-05-23
Thiol separation (Å)
3
Half-sphere exposure sum ?
81
Minimum pKa ?
6
% buried
100
Peptide accession
P15690
Residue number A
64
Residue number B
75
Peptide name
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Ligandability
Cysteine 64 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Cysteine 75 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
7ak5 G 55 G 69
A redox-regulated disulphide may form within NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial between cysteines 78 and 92 (55 and 69 respectively in this structure).
Details
Redox score ?
72
PDB code
7ak5
Structure name
cryo-em structure of respiratory complex i in the deactive state from mus musculus at 3
Structure deposition date
2020-09-29
Thiol separation (Å)
3
Half-sphere exposure sum ?
83
Minimum pKa ?
7
% buried
100
Peptide accession
Q91VD9
Residue number A
78
Residue number B
92
Peptide name
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Ligandability
Cysteine 78 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Cysteine 92 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
7qsn G 41 G 55
A redox-regulated disulphide may form within NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial between cysteines 64 and 78 (41 and 55 respectively in this structure).
Details
Redox score ?
65
PDB code
7qsn
Structure name
bovine complex i in lipid nanodisc, deactive-apo
Structure deposition date
2022-01-13
Thiol separation (Å)
6
Half-sphere exposure sum ?
87
Minimum pKa ?
2
% buried
100
Peptide accession
P15690
Residue number A
64
Residue number B
78
Peptide name
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Ligandability
Cysteine 64 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Cysteine 78 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
7r45 G 41 G 156
A redox-regulated disulphide may form within NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial between cysteines 64 and 179 (41 and 156 respectively in this structure).
Details
Redox score ?
62
PDB code
7r45
Structure name
bovine complex i in the presence of im1761092, deactive class i (composite map)
Structure deposition date
2022-02-08
Thiol separation (Å)
7
Half-sphere exposure sum ?
82
Minimum pKa ?
2
% buried
100
Peptide accession
P15690
Residue number A
64
Residue number B
179
Peptide name
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Ligandability
Cysteine 64 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Cysteine 179 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
7ak5 G 52 G 55
A redox-regulated disulphide may form within NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial between cysteines 75 and 78 (52 and 55 respectively in this structure).
Details
Redox score ?
60
PDB code
7ak5
Structure name
cryo-em structure of respiratory complex i in the deactive state from mus musculus at 3
Structure deposition date
2020-09-29
Thiol separation (Å)
5
Half-sphere exposure sum ?
82
Minimum pKa ?
7
% buried
100
Peptide accession
Q91VD9
Residue number A
75
Residue number B
78
Peptide name
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Ligandability
Cysteine 75 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Cysteine 78 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
7r4f G 153 G 203
A redox-regulated disulphide may form within NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial between cysteines 176 and 226 (153 and 203 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
7r4f
Structure name
bovine complex i in the presence of im1761092, slack class i (composite map)
Structure deposition date
2022-02-08
Thiol separation (Å)
7
Half-sphere exposure sum ?
87
Minimum pKa ?
10
% buried
100
Peptide accession
P15690
Residue number A
176
Residue number B
226
Peptide name
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Ligandability
Cysteine 176 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Cysteine 226 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
5ldx G 156 G 203
A redox-regulated disulphide may form within NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial between cysteines 179 and 226 (156 and 203 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
51
PDB code
5ldx
Structure name
structure of mammalian respiratory complex i, class3
Structure deposition date
2016-06-28
Thiol separation (Å)
6
Half-sphere exposure sum ?
78
Minimum pKa ?
11
% buried
96
Peptide accession
P15690
Residue number A
179
Residue number B
226
Peptide name
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Ligandability
Cysteine 179 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Cysteine 226 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
6g2j G 105 G 108
A redox-regulated disulphide may form within NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial between cysteines 128 and 131 (105 and 108 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
51
PDB code
6g2j
Structure name
mouse mitochondrial complex i in the active state
Structure deposition date
2018-03-23
Thiol separation (Å)
6
Half-sphere exposure sum ?
88
Minimum pKa ?
10
% buried
100
Peptide accession
Q91VD9
Residue number A
128
Residue number B
131
Peptide name
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Ligandability
Cysteine 128 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Cysteine 131 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
7ak6 G 153 G 156
A redox-regulated disulphide may form within NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial between cysteines 176 and 179 (153 and 156 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
7ak6
Structure name
cryo-em structure of nd6-p25l mutant respiratory complex i from mus musculus at 3
Structure deposition date
2020-09-29
Thiol separation (Å)
6
Half-sphere exposure sum ?
79
Minimum pKa ?
11
% buried
100
Peptide accession
Q91VD9
Residue number A
176
Residue number B
179
Peptide name
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Ligandability
Cysteine 176 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Cysteine 179 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
7ak6 G 156 G 159
A redox-regulated disulphide may form within NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial between cysteines 179 and 182 (156 and 159 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
7ak6
Structure name
cryo-em structure of nd6-p25l mutant respiratory complex i from mus musculus at 3
Structure deposition date
2020-09-29
Thiol separation (Å)
6
Half-sphere exposure sum ?
80
Minimum pKa ?
11
% buried
100
Peptide accession
Q91VD9
Residue number A
179
Residue number B
182
Peptide name
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Ligandability
Cysteine 179 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Cysteine 182 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
7qsl G 108 G 114
A redox-regulated disulphide may form within NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial between cysteines 131 and 137 (108 and 114 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
7qsl
Structure name
bovine complex i in lipid nanodisc, active-apo
Structure deposition date
2022-01-13
Thiol separation (Å)
6
Half-sphere exposure sum ?
85
Minimum pKa ?
10
% buried
100
Peptide accession
P15690
Residue number A
131
Residue number B
137
Peptide name
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Ligandability
Cysteine 131 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Cysteine 137 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
7ak5 G 153 G 159
A redox-regulated disulphide may form within NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial between cysteines 176 and 182 (153 and 159 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
7ak5
Structure name
cryo-em structure of respiratory complex i in the deactive state from mus musculus at 3
Structure deposition date
2020-09-29
Thiol separation (Å)
6
Half-sphere exposure sum ?
83
Minimum pKa ?
12
% buried
100
Peptide accession
Q91VD9
Residue number A
176
Residue number B
182
Peptide name
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Ligandability
Cysteine 176 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Cysteine 182 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
7dh0 A 182 A 226
A redox-regulated disulphide may form within NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial between cysteines 182 and 226. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
7dh0
Structure name
activity optimized complex i (open form)
Structure deposition date
2020-11-12
Thiol separation (Å)
7
Half-sphere exposure sum ?
79
Minimum pKa ?
12
% buried
100
Peptide accession
P15690
Residue number A
182
Residue number B
226
Peptide name
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Ligandability
Cysteine 182 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Cysteine 226 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
5ldw G 114 G 203
A redox-regulated disulphide may form within NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial between cysteines 137 and 226 (114 and 203 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
5ldw
Structure name
structure of mammalian respiratory complex i, class1
Structure deposition date
2016-06-28
Thiol separation (Å)
8
Half-sphere exposure sum ?
68
Minimum pKa ?
11
% buried
96
Peptide accession
P15690
Residue number A
137
Residue number B
226
Peptide name
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Ligandability
Cysteine 137 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Cysteine 226 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
7qsl G 105 G 114
A redox-regulated disulphide may form within NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial between cysteines 128 and 137 (105 and 114 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
7qsl
Structure name
bovine complex i in lipid nanodisc, active-apo
Structure deposition date
2022-01-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
88
Minimum pKa ?
13
% buried
100
Peptide accession
P15690
Residue number A
128
Residue number B
137
Peptide name
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Ligandability
Cysteine 128 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Cysteine 137 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
7qsk G 108 G 704
A redox-regulated disulphide may form within NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial between cysteines 131 and 727 (108 and 704 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
7qsk
Structure name
bovine complex i in lipid nanodisc, active-q10
Structure deposition date
2022-01-13
Thiol separation (Å)
10
Half-sphere exposure sum ?
nan
Minimum pKa ?
10
% buried
100
Peptide accession
P15690
Residue number A
131
Residue number B
727
Peptide name
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Ligandability
Cysteine 131 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Cysteine 727 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
7qsn G 52 G 156
A redox-regulated disulphide may form within NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial between cysteines 75 and 179 (52 and 156 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
7qsn
Structure name
bovine complex i in lipid nanodisc, deactive-apo
Structure deposition date
2022-01-13
Thiol separation (Å)
8
Half-sphere exposure sum ?
85
Minimum pKa ?
12
% buried
100
Peptide accession
P15690
Residue number A
75
Residue number B
179
Peptide name
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Ligandability
Cysteine 75 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Cysteine 179 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
7qsk G 108 G 203
A redox-regulated disulphide may form within NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial between cysteines 131 and 226 (108 and 203 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
7qsk
Structure name
bovine complex i in lipid nanodisc, active-q10
Structure deposition date
2022-01-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
88
Minimum pKa ?
9
% buried
100
Peptide accession
P15690
Residue number A
131
Residue number B
226
Peptide name
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Ligandability
Cysteine 131 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Cysteine 226 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
7dh0 A 367 A 554
A redox-regulated disulphide may form within NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial between cysteines 367 and 554. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
33
PDB code
7dh0
Structure name
activity optimized complex i (open form)
Structure deposition date
2020-11-12
Thiol separation (Å)
10
Half-sphere exposure sum ?
64
Minimum pKa ?
11
% buried
48
Peptide accession
P15690
Residue number A
367
Residue number B
554
Peptide name
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Ligandability
Cysteine 367 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Cysteine 554 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
7r43 G 30 G 55
A redox-regulated disulphide may form within NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial between cysteines 53 and 78 (30 and 55 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
33
PDB code
7r43
Structure name
bovine complex i in the presence of im1761092, active class iii (composite map)
Structure deposition date
2022-02-08
Thiol separation (Å)
10
Half-sphere exposure sum ?
85
Minimum pKa ?
8
% buried
100
Peptide accession
P15690
Residue number A
53
Residue number B
78
Peptide name
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Ligandability
Cysteine 53 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Cysteine 78 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
7b93 G 52 G 69
A redox-regulated disulphide may form within NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial between cysteines 75 and 92 (52 and 69 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
32
PDB code
7b93
Structure name
cryo-em structure of mitochondrial complex i from mus musculus inhibited by iacs-2858 at 3
Structure deposition date
2020-12-14
Thiol separation (Å)
6
Half-sphere exposure sum ?
86
Minimum pKa ?
18
% buried
100
Peptide accession
Q91VD9
Residue number A
75
Residue number B
92
Peptide name
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Ligandability
Cysteine 75 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Cysteine 92 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
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