ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

5-hydroxytryptamine receptor 2C

Intramolecular
Cysteine 337 and cysteine 341
Cysteine 127 and cysteine 207
A redox-regulated disulphide may form within 5-hydroxytryptamine receptor 2C between cysteines 337 and 341.

Details

Redox score ?
88
PDB code
6bqg
Structure name
crystal structure of 5-ht2c in complex with ergotamine
Structure deposition date
2017-11-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
33
Minimum pKa ?
nan
% buried
nan
Peptide accession
P28335
Residue number A
337
Residue number B
341
Peptide name
5-hydroxytryptamine receptor 2C

Ligandability

Cysteine 337 of 5-hydroxytryptamine receptor 2C

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 341 of 5-hydroxytryptamine receptor 2C

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 5-hydroxytryptamine receptor 2C between cysteines 127 and 207.

Details

Redox score ?
82
PDB code
6bqh
Structure name
crystal structure of 5-ht2c in complex with ritanserin
Structure deposition date
2017-11-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
P28335
Residue number A
127
Residue number B
207
Peptide name
5-hydroxytryptamine receptor 2C

Ligandability

Cysteine 127 of 5-hydroxytryptamine receptor 2C

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 207 of 5-hydroxytryptamine receptor 2C

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: