DNA polymerase delta catalytic subunit
Intermolecular
Cysteine 1011 and cysteine 27 of Proliferating cell nuclear antigen L
Intramolecular
Cysteine 1012 and cysteine 1029 L
Cysteine 1026 and cysteine 1029 L
Cysteine 1012 and cysteine 1026 L
Cysteine 1015 and cysteine 1026 L
Cysteine 1012 and cysteine 1015 L
Cysteine 1015 and cysteine 1029 L
Cysteine 338 and cysteine 512
Cysteine 1061 and cysteine 1071
Cysteine 1071 and cysteine 1076 L
More...Cysteine 1061 and cysteine 1076 L
Cysteine 138 and cysteine 284 L
Cysteine 1058 and cysteine 1071
Cysteine 1058 and cysteine 1061
Cysteine 1011 and cysteine 1012 L
Cysteine 1058 and cysteine 1076 L
Cysteine 1011 and cysteine 1026 L
Cysteine 338 and cysteine 360
Cysteine 138 and cysteine 139
Cysteine 1011 and cysteine 1015 L
Cysteine 617 and cysteine 713
Cysteine 319 and cysteine 512
6s1o A 1011 F 27
A redox-regulated disulphide may form between cysteine 1011 of DNA polymerase delta catalytic subunit and cysteine 27 of Proliferating cell nuclear antigen. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
6s1o
Structure name
human polymerase delta holoenzyme conformer 3
Structure deposition date
2019-06-19
Thiol separation (Å)
8
Half-sphere exposure sum ?
62
Minimum pKa ?
11
% buried
46
Peptide A name
DNA polymerase delta catalytic subunit
Peptide B name
Proliferating cell nuclear antigen
Peptide A accession
P28340
Peptide B accession
P12004
Peptide A residue number
1011
Peptide B residue number
27
Ligandability
Cysteine 1011 of DNA polymerase delta catalytic subunit
Cysteine 27 of Proliferating cell nuclear antigen
6s1m A 1012 A 1029
A redox-regulated disulphide may form within DNA polymerase delta catalytic subunit between cysteines 1012 and 1029.
Details
Redox score ?
88
PDB code
6s1m
Structure name
human polymerase delta holoenzyme conformer 1
Structure deposition date
2019-06-19
Thiol separation (Å)
3
Half-sphere exposure sum ?
50
Minimum pKa ?
7
% buried
14
Peptide accession
P28340
Residue number A
1012
Residue number B
1029
Peptide name
DNA polymerase delta catalytic subunit
Ligandability
Cysteine 1012 of DNA polymerase delta catalytic subunit
Cysteine 1029 of DNA polymerase delta catalytic subunit
6s1n A 1026 A 1029
A redox-regulated disulphide may form within DNA polymerase delta catalytic subunit between cysteines 1026 and 1029.
Details
Redox score ?
86
PDB code
6s1n
Structure name
human polymerase delta holoenzyme conformer 2
Structure deposition date
2019-06-19
Thiol separation (Å)
4
Half-sphere exposure sum ?
51
Minimum pKa ?
6
% buried
18
Peptide accession
P28340
Residue number A
1026
Residue number B
1029
Peptide name
DNA polymerase delta catalytic subunit
Ligandability
Cysteine 1026 of DNA polymerase delta catalytic subunit
Cysteine 1029 of DNA polymerase delta catalytic subunit
6s1n A 1012 A 1026
A redox-regulated disulphide may form within DNA polymerase delta catalytic subunit between cysteines 1012 and 1026.
Details
Redox score ?
81
PDB code
6s1n
Structure name
human polymerase delta holoenzyme conformer 2
Structure deposition date
2019-06-19
Thiol separation (Å)
4
Half-sphere exposure sum ?
61
Minimum pKa ?
6
% buried
26
Peptide accession
P28340
Residue number A
1012
Residue number B
1026
Peptide name
DNA polymerase delta catalytic subunit
Ligandability
Cysteine 1012 of DNA polymerase delta catalytic subunit
Cysteine 1026 of DNA polymerase delta catalytic subunit
6s1n A 1015 A 1026
A redox-regulated disulphide may form within DNA polymerase delta catalytic subunit between cysteines 1015 and 1026.
Details
Redox score ?
81
PDB code
6s1n
Structure name
human polymerase delta holoenzyme conformer 2
Structure deposition date
2019-06-19
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
6
% buried
32
Peptide accession
P28340
Residue number A
1015
Residue number B
1026
Peptide name
DNA polymerase delta catalytic subunit
Ligandability
Cysteine 1015 of DNA polymerase delta catalytic subunit
Cysteine 1026 of DNA polymerase delta catalytic subunit
6s1m A 1012 A 1015
A redox-regulated disulphide may form within DNA polymerase delta catalytic subunit between cysteines 1012 and 1015.
Details
Redox score ?
80
PDB code
6s1m
Structure name
human polymerase delta holoenzyme conformer 1
Structure deposition date
2019-06-19
Thiol separation (Å)
4
Half-sphere exposure sum ?
55
Minimum pKa ?
7
% buried
26
Peptide accession
P28340
Residue number A
1012
Residue number B
1015
Peptide name
DNA polymerase delta catalytic subunit
Ligandability
Cysteine 1012 of DNA polymerase delta catalytic subunit
Cysteine 1015 of DNA polymerase delta catalytic subunit
6s1m A 1015 A 1029
A redox-regulated disulphide may form within DNA polymerase delta catalytic subunit between cysteines 1015 and 1029.
Details
Redox score ?
77
PDB code
6s1m
Structure name
human polymerase delta holoenzyme conformer 1
Structure deposition date
2019-06-19
Thiol separation (Å)
4
Half-sphere exposure sum ?
47
Minimum pKa ?
10
% buried
18
Peptide accession
P28340
Residue number A
1015
Residue number B
1029
Peptide name
DNA polymerase delta catalytic subunit
Ligandability
Cysteine 1015 of DNA polymerase delta catalytic subunit
Cysteine 1029 of DNA polymerase delta catalytic subunit
6tny A 338 A 512
A redox-regulated disulphide may form within DNA polymerase delta catalytic subunit between cysteines 338 and 512.
Details
Redox score ?
72
PDB code
6tny
Structure name
processive human polymerase delta holoenzyme
Structure deposition date
2019-12-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
69
Minimum pKa ?
9
% buried
96
Peptide accession
P28340
Residue number A
338
Residue number B
512
Peptide name
DNA polymerase delta catalytic subunit
Ligandability
Cysteine 338 of DNA polymerase delta catalytic subunit
Cysteine 512 of DNA polymerase delta catalytic subunit
6s1o A 1061 A 1071
A redox-regulated disulphide may form within DNA polymerase delta catalytic subunit between cysteines 1061 and 1071.
Details
Redox score ?
63
PDB code
6s1o
Structure name
human polymerase delta holoenzyme conformer 3
Structure deposition date
2019-06-19
Thiol separation (Å)
6
Half-sphere exposure sum ?
46
Minimum pKa ?
10
% buried
58
Peptide accession
P28340
Residue number A
1061
Residue number B
1071
Peptide name
DNA polymerase delta catalytic subunit
Ligandability
Cysteine 1061 of DNA polymerase delta catalytic subunit
Cysteine 1071 of DNA polymerase delta catalytic subunit
6s1m A 1071 A 1076
A redox-regulated disulphide may form within DNA polymerase delta catalytic subunit between cysteines 1071 and 1076.
Details
Redox score ?
61
PDB code
6s1m
Structure name
human polymerase delta holoenzyme conformer 1
Structure deposition date
2019-06-19
Thiol separation (Å)
6
Half-sphere exposure sum ?
54
Minimum pKa ?
10
% buried
59
Peptide accession
P28340
Residue number A
1071
Residue number B
1076
Peptide name
DNA polymerase delta catalytic subunit
Ligandability
Cysteine 1071 of DNA polymerase delta catalytic subunit
Cysteine 1076 of DNA polymerase delta catalytic subunit
6s1m A 1061 A 1076
A redox-regulated disulphide may form within DNA polymerase delta catalytic subunit between cysteines 1061 and 1076.
Details
Redox score ?
61
PDB code
6s1m
Structure name
human polymerase delta holoenzyme conformer 1
Structure deposition date
2019-06-19
Thiol separation (Å)
6
Half-sphere exposure sum ?
51
Minimum pKa ?
11
% buried
54
Peptide accession
P28340
Residue number A
1061
Residue number B
1076
Peptide name
DNA polymerase delta catalytic subunit
Ligandability
Cysteine 1061 of DNA polymerase delta catalytic subunit
Cysteine 1076 of DNA polymerase delta catalytic subunit
6s1n A 138 A 284
A redox-regulated disulphide may form within DNA polymerase delta catalytic subunit between cysteines 138 and 284. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
59
PDB code
6s1n
Structure name
human polymerase delta holoenzyme conformer 2
Structure deposition date
2019-06-19
Thiol separation (Å)
5
Half-sphere exposure sum ?
76
Minimum pKa ?
11
% buried
88
Peptide accession
P28340
Residue number A
138
Residue number B
284
Peptide name
DNA polymerase delta catalytic subunit
Ligandability
Cysteine 138 of DNA polymerase delta catalytic subunit
Cysteine 284 of DNA polymerase delta catalytic subunit
6s1o A 1058 A 1071
A redox-regulated disulphide may form within DNA polymerase delta catalytic subunit between cysteines 1058 and 1071. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
56
PDB code
6s1o
Structure name
human polymerase delta holoenzyme conformer 3
Structure deposition date
2019-06-19
Thiol separation (Å)
6
Half-sphere exposure sum ?
60
Minimum pKa ?
10
% buried
69
Peptide accession
P28340
Residue number A
1058
Residue number B
1071
Peptide name
DNA polymerase delta catalytic subunit
Ligandability
Cysteine 1058 of DNA polymerase delta catalytic subunit
Cysteine 1071 of DNA polymerase delta catalytic subunit
6s1n A 1058 A 1061
A redox-regulated disulphide may form within DNA polymerase delta catalytic subunit between cysteines 1058 and 1061. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
54
PDB code
6s1n
Structure name
human polymerase delta holoenzyme conformer 2
Structure deposition date
2019-06-19
Thiol separation (Å)
6
Half-sphere exposure sum ?
55
Minimum pKa ?
11
% buried
63
Peptide accession
P28340
Residue number A
1058
Residue number B
1061
Peptide name
DNA polymerase delta catalytic subunit
Ligandability
Cysteine 1058 of DNA polymerase delta catalytic subunit
Cysteine 1061 of DNA polymerase delta catalytic subunit
6tnz A 1011 A 1012
A redox-regulated disulphide may form within DNA polymerase delta catalytic subunit between cysteines 1011 and 1012. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
6tnz
Structure name
human polymerase delta-fen1-pcna toolbelt
Structure deposition date
2019-12-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
58
Minimum pKa ?
7
% buried
32
Peptide accession
P28340
Residue number A
1011
Residue number B
1012
Peptide name
DNA polymerase delta catalytic subunit
Ligandability
Cysteine 1011 of DNA polymerase delta catalytic subunit
Cysteine 1012 of DNA polymerase delta catalytic subunit
6tnz A 1058 A 1076
A redox-regulated disulphide may form within DNA polymerase delta catalytic subunit between cysteines 1058 and 1076. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
51
PDB code
6tnz
Structure name
human polymerase delta-fen1-pcna toolbelt
Structure deposition date
2019-12-10
Thiol separation (Å)
7
Half-sphere exposure sum ?
63
Minimum pKa ?
11
% buried
64
Peptide accession
P28340
Residue number A
1058
Residue number B
1076
Peptide name
DNA polymerase delta catalytic subunit
Ligandability
Cysteine 1058 of DNA polymerase delta catalytic subunit
Cysteine 1076 of DNA polymerase delta catalytic subunit
6s1o A 1011 A 1026
A redox-regulated disulphide may form within DNA polymerase delta catalytic subunit between cysteines 1011 and 1026. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
6s1o
Structure name
human polymerase delta holoenzyme conformer 3
Structure deposition date
2019-06-19
Thiol separation (Å)
10
Half-sphere exposure sum ?
59
Minimum pKa ?
6
% buried
36
Peptide accession
P28340
Residue number A
1011
Residue number B
1026
Peptide name
DNA polymerase delta catalytic subunit
Ligandability
Cysteine 1011 of DNA polymerase delta catalytic subunit
Cysteine 1026 of DNA polymerase delta catalytic subunit
6s1o A 338 A 360
A redox-regulated disulphide may form within DNA polymerase delta catalytic subunit between cysteines 338 and 360. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
6s1o
Structure name
human polymerase delta holoenzyme conformer 3
Structure deposition date
2019-06-19
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
9
% buried
72
Peptide accession
P28340
Residue number A
338
Residue number B
360
Peptide name
DNA polymerase delta catalytic subunit
Ligandability
Cysteine 338 of DNA polymerase delta catalytic subunit
Cysteine 360 of DNA polymerase delta catalytic subunit
6s1n A 138 A 139
A redox-regulated disulphide may form within DNA polymerase delta catalytic subunit between cysteines 138 and 139. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
6s1n
Structure name
human polymerase delta holoenzyme conformer 2
Structure deposition date
2019-06-19
Thiol separation (Å)
7
Half-sphere exposure sum ?
84
Minimum pKa ?
12
% buried
93
Peptide accession
P28340
Residue number A
138
Residue number B
139
Peptide name
DNA polymerase delta catalytic subunit
Ligandability
Cysteine 138 of DNA polymerase delta catalytic subunit
Cysteine 139 of DNA polymerase delta catalytic subunit
6s1m A 1011 A 1015
A redox-regulated disulphide may form within DNA polymerase delta catalytic subunit between cysteines 1011 and 1015. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
6s1m
Structure name
human polymerase delta holoenzyme conformer 1
Structure deposition date
2019-06-19
Thiol separation (Å)
10
Half-sphere exposure sum ?
53
Minimum pKa ?
10
% buried
34
Peptide accession
P28340
Residue number A
1011
Residue number B
1015
Peptide name
DNA polymerase delta catalytic subunit
Ligandability
Cysteine 1011 of DNA polymerase delta catalytic subunit
Cysteine 1015 of DNA polymerase delta catalytic subunit
6tny A 617 A 713
A redox-regulated disulphide may form within DNA polymerase delta catalytic subunit between cysteines 617 and 713. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
6tny
Structure name
processive human polymerase delta holoenzyme
Structure deposition date
2019-12-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
74
Minimum pKa ?
9
% buried
90
Peptide accession
P28340
Residue number A
617
Residue number B
713
Peptide name
DNA polymerase delta catalytic subunit
Ligandability
Cysteine 617 of DNA polymerase delta catalytic subunit
Cysteine 713 of DNA polymerase delta catalytic subunit
6s1n A 319 A 512
A redox-regulated disulphide may form within DNA polymerase delta catalytic subunit between cysteines 319 and 512. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
29
PDB code
6s1n
Structure name
human polymerase delta holoenzyme conformer 2
Structure deposition date
2019-06-19
Thiol separation (Å)
10
Half-sphere exposure sum ?
66
Minimum pKa ?
12
% buried
88
Peptide accession
P28340
Residue number A
319
Residue number B
512
Peptide name
DNA polymerase delta catalytic subunit
Ligandability
Cysteine 319 of DNA polymerase delta catalytic subunit
Cysteine 512 of DNA polymerase delta catalytic subunit
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