ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Transcriptional enhancer factor TEF-1

Intramolecular
Cysteine 402 and cysteine 405
Cysteine 327 and cysteine 405
A redox-regulated disulphide may form within Transcriptional enhancer factor TEF-1 between cysteines 402 and 405. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
6im5
Structure name
yap-binding domain of human tead1
Structure deposition date
2018-10-22
Thiol separation (Å)
8
Half-sphere exposure sum ?
83
Minimum pKa ?
12
% buried
100
Peptide accession
P28347
Residue number A
402
Residue number B
405
Peptide name
Transcriptional enhancer factor TEF-1

Ligandability

Cysteine 402 of Transcriptional enhancer factor TEF-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 405 of Transcriptional enhancer factor TEF-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcriptional enhancer factor TEF-1 between cysteines 327 and 405 (312 and 390 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
3kys
Structure name
crystal structure of human yap and tead complex
Structure deposition date
2009-12-07
Thiol separation (Å)
9
Half-sphere exposure sum ?
78
Minimum pKa ?
11
% buried
100
Peptide accession
P28347
Residue number A
327
Residue number B
405
Peptide name
Transcriptional enhancer factor TEF-1

Ligandability

Cysteine 327 of Transcriptional enhancer factor TEF-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 405 of Transcriptional enhancer factor TEF-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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